Journal article
Utility of different blood pressure measurement components in childhood to predict adult carotid intima media thickness. The i3C Consortium Study
Hypertension (Dallas, Tex. 1979), Vol.73(2), pp.335-341
02/01/2019
DOI: 10.1161/HYPERTENSIONAHA.118.12225
PMCID: PMC6326843
PMID: 30580683
Abstract
Childhood blood pressure levels predict adult subclinical atherosclerosis. However, the best childhood blood pressure component for prediction has not been determined. This study comprised 5,925 participants aged 3–18 years from six cohorts who were followed into adulthood (mean follow-up 25.8±6.2 years). Childhood blood pressure was measured by using a standard mercury sphygmomanometer in all cohorts. Study-specific carotid intima-media thickness ≥90
th
percentile was used to define subclinical atherosclerosis. Per standard deviation change in the predictor, childhood systolic blood pressure (age- and sex-adjusted Odds Ratio [95% confidence interval] 1.24[1.13–1.37]), mean arterial pressure (1.10[1.07–1.13]) and pulse pressure (1.15 [1.05–1.27]) were associated with increased adulthood intima-media thickness. In age-and sex-adjusted analyses, area under the receiver-operating characteristic curves for systolic blood pressure (c-value [95% confidence interval] 0.677[0.657–0.704]) showed significantly improved prediction compared to diastolic blood pressure (0.669[0.646–0.693], P=0.006), or mean arterial pressure (0.674[0.653–0.699] P=0.01). Pulse pressure provided a c-value that was not different from systolic blood pressure (0.676[0.653–0.699] P=0.16). Combining different blood pressure components did not improve prediction over systolic blood pressure measurement alone. Based on the associations with adult carotid intima-media thickness, cut-points for elevated systolic blood pressure were 105 mmHg for 3–6 year-old boys, 108 mmHg for 3–6 year-old girls, 108 mmHg for 7–12 year-old boys, 106 mmHg for 7–12 year-old girls, 123 mmHg for 13–18 year-old boys and 115 mmHg for 13–18 year-old girls. Our analyses suggest that several childhood blood pressure measurement components are related to adulthood carotid intima-media thickness. Of these, systolic blood pressure provided the best predictive ability.
Details
- Title: Subtitle
- Utility of different blood pressure measurement components in childhood to predict adult carotid intima media thickness. The i3C Consortium Study
- Creators
- Juha Koskinen - University of TurkuMarkus Juonala - Turku University HospitalTerence Dwyer - George Institute for Global HealthAlison Venn - Menzies Research InstituteJanina Petkeviciene - Lithuanian University of Health SciencesIndrė Čeponienė - Lithuanian University of Health SciencesLydia Bazzano - Tulane UniversityWei Chen - Tulane UniversityMatthew A. Sabin - Royal Children's HospitalTrudy L. Burns - University of IowaJorma S.A. ViikariJessica G. Woo - Cincinnati Children's Hospital Medical CenterElaine M. Urbina - Cincinnati Children's Hospital Medical CenterRonald Prineas - Wake Forest UniversityNina Hutri-Kähönen - University of TampereAlan Sinaiko - University of MinnesotaDavid R. Jacobs - University of MinnesotaJulia Steinberger - University of MinnesotaStephen Daniels - Children's Hospital ColoradoOlli Raitakari - University of TurkuCostan G. Magnussen - University of Turku
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.73(2), pp.335-341
- DOI
- 10.1161/HYPERTENSIONAHA.118.12225
- PMID
- 30580683
- PMCID
- PMC6326843
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 02/01/2019
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984364450702771
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