Utility of late N-isopropyl-p-(iodine-123)-iodoamphetamine brain distribution in predicting outcome following cerebral infarction

S Gupta; D L Bushnell; A Mlcoch; G Eastman; W E Barnes; S G Fisher

doi:10.1161/01.STR.22.12.1512

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Utility of late N-isopropyl-p-(iodine-123)-iodoamphetamine brain distribution in predicting outcome following cerebral infarction

Journal article

Open access

Peer reviewed

Utility of late N-isopropyl-p-(iodine-123)-iodoamphetamine brain distribution in predicting outcome following cerebral infarction

S Gupta, D L Bushnell, A Mlcoch, G Eastman, W E Barnes and S G Fisher

Stroke (1970), Vol.22(12), pp.1512-1518

12/1991

DOI: 10.1161/01.STR.22.12.1512

PMID: 1962326

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Abstract

The purpose of this study was to determine utility of late N-isopropyl-p-(iodine-123)-iodoamphetamine distribution in predicting neurological and language outcome. We prospectively studied 29 patients with unilateral hemispheric ischemic cerebral infarction using the neuroimaging method of single-photon emission computed tomography and the above tracer. Four different imaging measures reflecting late tracer distribution or redistribution and three measures indicative of the patients' overall neurological or language outcome at 3 months were used in the data analysis. All patients had neuroimaging within 30 days of infarction, and 14 patients were imaged within 10 days of infarction. Data analysis was performed for all patients combined and then separately on the groups imaged within 10 days of and more than 10 days after infarction. The volume of the late image defect significantly correlated with one measure of neurological outcome in the whole group and in those imaged more than 10 days after cerebral infarction. However, these results are difficult to explain based on the present understanding of the physiology of late N-isopropyl-p-(iodine-123)-iodoamphetamine distribution. We feel that the pattern of late N-isopropyl-p-(iodine-123)-iodoamphetamine distribution is probably not useful as an independent predictor of neurological and language outcome.

Aged

Amphetamines

Brain - diagnostic imaging

Cerebral Infarction - diagnostic imaging

Cerebral Infarction - physiopathology

Cerebral Infarction - psychology

Humans

Iodine Radioisotopes

Iofetamine

Language

Male

Middle Aged

Nervous System - physiopathology

Tomography, Emission-Computed

Details

Title: Subtitle: Utility of late N-isopropyl-p-(iodine-123)-iodoamphetamine brain distribution in predicting outcome following cerebral infarction
Creators: S Gupta - Veterans Health Administration
D L Bushnell - Veterans Health Administration
A Mlcoch - Veterans Health Administration
G Eastman - Veterans Health Administration
W E Barnes - Veterans Health Administration
S G Fisher - Veterans Health Administration
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.22(12), pp.1512-1518
DOI: 10.1161/01.STR.22.12.1512
PMID: 1962326
NLM abbreviation: Stroke
ISSN: 0039-2499
eISSN: 1524-4628
Language: English
Date published: 12/1991
Academic Unit: Radiology
Record Identifier: 9984318795002771

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