Utility of meibography in the evaluation of meibomian glands morphology in normal and diseased eyelids

Adel H Alsuhaibani; Keith D Carter; Michael D Abràmoff; Jeffrey A Nerad

doi:10.1016/j.sjopt.2010.10.005

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Utility of meibography in the evaluation of meibomian glands morphology in normal and diseased eyelids

Journal article

Open access

Peer reviewed

Utility of meibography in the evaluation of meibomian glands morphology in normal and diseased eyelids

Adel H Alsuhaibani, Keith D Carter, Michael D Abràmoff and Jeffrey A Nerad

Saudi Journal of Ophthalmology, Vol.25(1), pp.61-66

2011

DOI: 10.1016/j.sjopt.2010.10.005

PMCID: PMC3729445

PMID: 23960903

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Abstract

To study the utility of meibography for the morphology of meibomian glands in normal eyelids and in various eyelid diseases. A cross-sectional study. A newly designed transilluminator, fitting both the upper along with lower eyelids, and an infrared camera were used to obtain video clips of the meibomian glands for 60 asymptomatic subjects with normal eyelid margin. Parameters studied included, ocular surface, Schirmer test, and tear breakup time (TBUT). The meibomian glands of patients with meibomian glands’ abnormality secondary to infectious, inflammatory, malignant, congenital, or post-radiation therapy disease related etiologies were compared with normal patients. Still pictures were extracted from the video clips to evaluate the meibomian glands for gland dropout and gross morphological changes. In normal subjects, meibomian glands appeared to be thinner and longer in the upper eye lids than in the lower eye lids. Gland dropout occured with increased age, more in the lower eye lid and in females. Excessive gland drop out (> 75%) was seen in patients with history of trachoma, Stevens Johnson syndrome, severe blepharitis, and post-radiation for orbital tumors. Variable gland drop out was noticed in patients with floppy eyelid syndrome, and blepharitis. In patients with congenital distichiasis, partial or complete gland drop out at the part of the eyelid margins affected by distichiasis was noticed. The newly designed transilluminator permitted the examination of both upper and lower eye lid meibomian glands with minimal discomfort. Evaluating the anatomical changes involving meibomian glands with meibography may help increase our understanding of the meibomian gland-related diseases, monitor the effects of treatment, and provide helpful information for patient education.

Blepharitis

Distichiasis

Chalazion

Dry eye

Radiation

Trachoma

Meibography

Meibomian glands

Details

Title: Subtitle: Utility of meibography in the evaluation of meibomian glands morphology in normal and diseased eyelids
Creators: Adel H Alsuhaibani - Department of Ophthalmology, King Abdulaziz University Hospital, King Saud University, Riyadh, Saudi Arabia
Keith D Carter - Department of Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, Iowa City, IA, USA
Michael D Abràmoff - Department of Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, Iowa City, IA, USA
Jeffrey A Nerad - Cincinnati Eye Institute, Cincinnati, OH, USA
Resource Type: Journal article
Publication Details: Saudi Journal of Ophthalmology, Vol.25(1), pp.61-66
DOI: 10.1016/j.sjopt.2010.10.005
PMID: 23960903
PMCID: PMC3729445
NLM abbreviation: Saudi J Ophthalmol
ISSN: 1319-4534
Publisher: Elsevier B.V
Language: English
Date published: 2011
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Otolaryngology; Ophthalmology and Visual Sciences
Record Identifier: 9983806369202771

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