Journal article
Utility of narrow band imaging in predicting histology in celiac disease
Indian journal of gastroenterology, Vol.39(4), pp.370-376
08/01/2020
DOI: 10.1007/s12664-020-01030-1
PMID: 32705418
Abstract
Background Narrow band imaging (NBI) with magnification better visualizes the duodenal microsurface and mucosal vascularity. NBI delineates villous atrophy better than conventional white light endoscopy. Aims This study was conducted to evaluate the diagnostic accuracy of narrow band imaging with magnification (NBI-ME) in celiac disease (CD). Methods In this prospective study, consecutive patients of suspected CD and controls were subjected to tissue transglutaminase antibody test and endoscopic evaluation initially with white light followed by NBI-ME, and biopsies were taken from duodenum. Duodenal villous patterns on NBI were interpreted as normal, blunted distorted, and absent. Severity of villous atrophy was reported according to the modified Marsh criteria. Results One hundred and twenty-two patients (mean age of 27.53 +/- 13.37 years and a male to female ratio of 1:1.26) and 40 controls were studied. The sensitivity and specificity of NBI-ME in predicting villous atrophy were found to be 95.54% and 90%, respectively. The specificity and negative predictive value of NBI-ME in predicting villous atrophy amongst controls was 100% and 97.5%, respectively. Abnormal findings (blunted and absent villous patterns) combined with elevated transglutaminase antibody (> 5-fold) were found to have high accuracy in predicting villous atrophy. Conclusion NBI with magnification has high sensitivity and specificity in predicting villous atrophy in patients with celiac disease.
Details
- Title: Subtitle
- Utility of narrow band imaging in predicting histology in celiac disease
- Creators
- Saroj Kant Sinha - Post Graduate Institute of Medical Education and ResearchNeha Berry - Post Graduate Institute of Medical Education and ResearchGaurav Muktesh - Post Graduate Institute of Medical Education and ResearchPradeep Siddappa - Post Graduate Institute of Medical Education and ResearchJahangeer Basha - Post Graduate Institute of Medical Education and ResearchKaushal Prasad - Post Graduate Institute of Medical Education and ResearchSreekanth Appasani - Post Graduate Institute of Medical Education and ResearchMunish Ashat - Post Graduate Institute of Medical Education and ResearchKim Vaiphei - Post Graduate Institute of Medical Education and ResearchKartar Singh - Post Graduate Institute of Medical Education and ResearchRakesh Kochhar - Post Graduate Institute of Medical Education and Research
- Resource Type
- Journal article
- Publication Details
- Indian journal of gastroenterology, Vol.39(4), pp.370-376
- Publisher
- Springer Nature
- DOI
- 10.1007/s12664-020-01030-1
- PMID
- 32705418
- ISSN
- 0254-8860
- eISSN
- 0975-0711
- Number of pages
- 7
- Language
- English
- Date published
- 08/01/2020
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984359679902771
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