Journal article
Utility of radiolabeled somatostatin receptor analogues for staging/restaging and treatment of somatostatin receptor-positive pediatric tumors
The oncologist (Dayton, Ohio), Vol.13(4), pp.382-389
01/01/2008
DOI: 10.1634/theoncologist.2007-0175
PMID: 18448552
Abstract
In this paper, we review the pediatric oncologic applications of somatostatin receptor-targeted imaging and therapy. Somatostatin receptors are expressed in high densities by embryonal tumors, such as neuroblastoma and medulloblastoma, and neuroendocrine tumors like carcinoids and islet cell tumors. We first review the distribution of these receptors in normal tissues and tumor cells. We then discuss the technique of somatostatin receptor scintigraphy (SRS) in the pediatric population. Next, the specific clinical applications of SRS with regard to the imaging of neuroblastoma, central nervous system tumors, and gastroenteropancreatic neuroendocrine tumors of childhood are discussed. Finally, we discuss the potential role of somatostatin receptor-targeted radiotherapy for improving the duration and quality of life of children with these tumors.
Details
- Title: Subtitle
- Utility of radiolabeled somatostatin receptor analogues for staging/restaging and treatment of somatostatin receptor-positive pediatric tumors
- Creators
- Geetika Khanna - Departments of aRadiology andDavid Bushnell - Departments of aRadiology andM. Sue O'Dorisio - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- The oncologist (Dayton, Ohio), Vol.13(4), pp.382-389
- Publisher
- Wiley
- DOI
- 10.1634/theoncologist.2007-0175
- PMID
- 18448552
- ISSN
- 1083-7159
- eISSN
- 1549-490X
- Number of pages
- 8
- Grant note
- R01CA167632 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 01/01/2008
- Academic Unit
- Radiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984318795302771
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