Journal article
Utility of the Chronic Disease Score and Charlson Comorbidity Index as comorbidity measures for use in epidemiologic studies of antibiotic-resistant organisms
American journal of epidemiology, Vol.161(5), pp.483-493
03/01/2005
DOI: 10.1093/aje/kwi068
PMID: 15718484
Abstract
Comorbidity is a known risk factor for antibiotic-resistant bacterial infections. Although aggregate comorbidity measures are useful in epidemiologic research, none of the existing measures was developed for use with this outcome. This study compared the utility of two comorbidity measures, the Charlson Comorbidity Index and the Chronic Disease Score, in assessing the comorbidity-attributable risk of nosocomial infections with methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant enterococci (VRE). Two case-control studies were conducted at the University of Maryland Medical System in Baltimore, Maryland. Cases were inpatients with a first positive clinical culture of MRSA or VRE at least 48 hours postadmission (July 1, 1998-July 1, 2001). Three inpatient controls were randomly selected per case. The MRSA study included 2,164 patients, and the VRE study included 1,948. The scores' discrimination and calibration were measured by using the c statistic and Hosmer-Lemeshow chi-square test. The Charlson Comorbidity Index (c = 0.653) and Chronic Disease Score (c = 0.608) were similar discriminators of MRSA and VRE (c = 0.670 and c = 0.647, respectively). Calibration of the scores was poor for both outcomes (p < 0.05). A revised comorbidity measure specific to resistant infections would likely provide a better assessment of the comorbidity-attributable risk of antibiotic-resistant infections.
Details
- Title: Subtitle
- Utility of the Chronic Disease Score and Charlson Comorbidity Index as comorbidity measures for use in epidemiologic studies of antibiotic-resistant organisms
- Creators
- Jessina C McGregor - Department of Epidemiology and Preventive Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA. jmcgrego@epi.umaryland.eduPeter W KimEli N PerencevichDouglas D BradhamJon P FurunoKeith S KayeJeffrey C FinkPatricia LangenbergMary-Claire RoghmannAnthony D Harris
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.161(5), pp.483-493
- Publisher
- United States
- DOI
- 10.1093/aje/kwi068
- PMID
- 15718484
- ISSN
- 0002-9262
- eISSN
- 1476-6256
- Language
- English
- Date published
- 03/01/2005
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983779493702771
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