Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy

Zain Mehdi; Michael S. Petronek; Jeffrey M. Stolwijk; Kranti A. Mapuskar; Amanda L. Kalen; Garry R. Buettner; Joseph J. Cullen; Douglas R. Spitz; John M. Buatti; Bryan G. Allen

doi:10.3390/ijms221910880

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Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy

Journal article

Open access

Peer reviewed

Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy

Zain Mehdi, Michael S. Petronek, Jeffrey M. Stolwijk, Kranti A. Mapuskar, Amanda L. Kalen, Garry R. Buettner, Joseph J. Cullen, Douglas R. Spitz, John M. Buatti and Bryan G. Allen

International journal of molecular sciences, Vol.22(19), p.10880

10/01/2021

DOI: 10.3390/ijms221910880

PMCID: PMC8509557

PMID: 34639220

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Abstract

Interest in the use of pharmacological ascorbate as a treatment for cancer has increased considerably since it was introduced by Cameron and Pauling in the 1970s. Recently, pharmacological ascorbate has been used in preclinical and early-phase clinical trials as a selective radiation sensitizer in cancer. The results of these studies are promising. This review summarizes data on pharmacological ascorbate (1) as a safe and efficacious adjuvant to cancer therapy; (2) as a selective radiosensitizer of cancer via a mechanism involving hydrogen peroxide; and (3) as a radioprotector in normal tissues. Additionally, we present new data demonstrating the ability of pharmacological ascorbate to enhance radiation-induced DNA damage in glioblastoma cells, facilitating cancer cell death. We propose that pharmacological ascorbate may be a general radiosensitizer in cancer therapy and simultaneously a radioprotector of normal tissue.

Biochemistry & Molecular Biology

Chemistry

Chemistry, Multidisciplinary

Life Sciences & Biomedicine

Physical Sciences

Science & Technology

Details

Title: Subtitle: Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy
Creators: Zain Mehdi - University of Iowa
Michael S. Petronek - University of Iowa
Jeffrey M. Stolwijk - University of Iowa
Kranti A. Mapuskar - University of Iowa
Amanda L. Kalen - University of Iowa
Garry R. Buettner - University of Iowa
Joseph J. Cullen - University of Iowa
Douglas R. Spitz - University of Iowa
John M. Buatti - University of Iowa
Bryan G. Allen - University of Iowa
Resource Type: Journal article
Publication Details: International journal of molecular sciences, Vol.22(19), p.10880
DOI: 10.3390/ijms221910880
PMID: 34639220
PMCID: PMC8509557
NLM abbreviation: Int J Mol Sci
ISSN: 1661-6596
eISSN: 1422-0067
Publisher: Mdpi
Number of pages: 15
Grant note: Gateway for Cancer Research Grant Carver College of Medicine NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
Language: English
Date published: 10/01/2021
Academic Unit: Pathology; Iowa Neuroscience Institute; Surgery; Radiation Oncology; Radiation Research Laboratory; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Otolaryngology
Record Identifier: 9984303898102771

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