Journal article
Utilizing Artificial Intelligence-Based Deformable Registration for Global and Layer-Specific Cardiac MRI Strain Analysis in Healthy Children and Young Adults
Academic radiology, Vol.31(4), pp.1643-1654
04/2024
DOI: 10.1016/j.acra.2023.12.029
PMID: 38177034
Abstract
The absence of published reference values for multilayer-specific strain measurement using cardiac magnetic resonance (CMR) in young healthy individuals limits its use. This study aimed to establish normal global and layer-specific strain values in healthy children and young adults using a deformable registration algorithm (DRA).
A retrospective study included 131 healthy children and young adults (62 males and 69 females) with a mean age of 16.6 ± 3.9 years. CMR examinations were conducted using 1.5T scanners, and strain analysis was performed using TrufiStrain research prototype software (Siemens Healthineers, Erlangen, Germany). Global and layer-specific strain parameters were extracted from balanced Steady-state free precession cine images. Statistical analyses were conducted to evaluate the impact of demographic variables on strain measurements.
The peak global longitudinal strain (LS) was -16.0 ± 3.0%, peak global radial strain (RS) was 29.9 ± 6.3%, and peak global circumferential strain (CS) was -17.0 ± 1.8%. Global LS differed significantly between males and females. Transmural strain analysis showed a consistent pattern of decreasing LS and CS from endocardium to epicardium, while radial strain increased. Basal-to-apical strain distribution exhibited decreasing LS and increasing CS in both global and layer-specific analysis.
This study uses DRA to provide reference values for global and layer-specific strain in healthy children and young adults. The study highlights the impact of sex and age on LS and body mass index on RS. These insights are vital for future cardiac assessments in children, particularly for early detection of heart diseases.
Details
- Title: Subtitle
- Utilizing Artificial Intelligence-Based Deformable Registration for Global and Layer-Specific Cardiac MRI Strain Analysis in Healthy Children and Young Adults
- Creators
- Sarv Priya - Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 (S.P., T.H., S.G., O.A.F.D.P., A.W.). Electronic address: sarv-priya@uiowa.eduTyler Hartigan - Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 (S.P., T.H., S.G., O.A.F.D.P., A.W.)Sarah S Perry - Department of Biostatistics, University of Iowa, Iowa City, Iowa (S.S.P.)Sawyer Goetz - Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 (S.P., T.H., S.G., O.A.F.D.P., A.W.)Otavio Augusto Ferreira Dalla PriaAbigail Walling - University of IowaPrashant Nagpal - University of Wisconsin School of Medicine and Public HealthRavi Ashwath - University of IowaXiaoming Bi - MR R&D, Siemens Medical Solutions USA, Inc., Los Angeles, California (X.B.)Teodora Chitiboi - Siemens Healthcare GmbH, Hamburg, Germany (T.C.)
- Resource Type
- Journal article
- Publication Details
- Academic radiology, Vol.31(4), pp.1643-1654
- DOI
- 10.1016/j.acra.2023.12.029
- PMID
- 38177034
- eISSN
- 1878-4046
- Language
- English
- Electronic publication date
- 01/03/2024
- Date published
- 04/2024
- Academic Unit
- Radiology; Occupational and Environmental Health; Stead Family Department of Pediatrics
- Record Identifier
- 9984539652002771
Metrics
8 Record Views