Uveitis following intravitreal bevacizumab: a non-infectious cluster

Christine N Kay; Ryan M Tarantola; Karen M Gehrs; James C Folk; Vinit B Mahajan; H Culver Boldt; Nasreen A Syed; Stephen R Russell

doi:10.3928/15428877-20110603-04

Journal article

Uveitis following intravitreal bevacizumab: a non-infectious cluster

Christine N Kay, Ryan M Tarantola, Karen M Gehrs, James C Folk, Vinit B Mahajan, H Culver Boldt, Nasreen A Syed and Stephen R Russell

Ophthalmic surgery, lasers & imaging, Vol.42(4), pp.292-296

07/2011

DOI: 10.3928/15428877-20110603-04

PMID: 21800802

View Online

Abstract

In this retrospective case series, the authors report seven cases of bevacizumab-related uveitis that occurred within a 4-month period. Seven eyes of six patients developed non-infectious uveitis following bevacizumab intravitreal injections in a cohort of 978 consecutive bevacizumab injections. The mean age of patients was 74.6 years (range: 26 to 92). All patients developed symptom onset within 1 day of injection. Shared signs and symptoms included corneal edema, anterior chamber and vitreous cell, conjunctival injection, ocular pain, and lack of hypopyon. In all patients, visual acuity returned to within one line of baseline acuity. All seven eyes had been previously injected with bevacizumab, with a mean number of antecedent injections of 6.1 (range: 3 to 12). A cluster of sterile bevacizumab-related uveitic reactions was described in this case series. Acute onset of symptoms, absence of hypopyon, a predominant anterior segment reaction, and prompt improvement on topical steroid therapy are useful clinical features distinguishing this uveitic syndrome from infectious endophthalmitis.

Intravitreal Injections

Humans

Middle Aged

Antibodies, Monoclonal - adverse effects

Vascular Endothelial Growth Factor A - antagonists & inhibitors

Uveitis, Anterior - chemically induced

Bevacizumab

Antibodies, Monoclonal, Humanized

Aged, 80 and over

Adult

Uveitis, Anterior - diagnosis

Aged

Retrospective Studies

Angiogenesis Inhibitors - adverse effects

Visual Acuity - physiology

Immunosuppressive Agents - administration & dosage

Uveitis, Anterior - drug therapy

Details

Title: Subtitle: Uveitis following intravitreal bevacizumab: a non-infectious cluster
Creators: Christine N Kay - Vitreoretinal Service, Department of Ophthalmology & Visual Sciences, Carver School of Medicine, The University of Iowa, Iowa City, Iowa, USA. christinemnichols@hotmail.com
Ryan M Tarantola
Karen M Gehrs
James C Folk
Vinit B Mahajan
H Culver Boldt
Nasreen A Syed
Stephen R Russell
Resource Type: Journal article
Publication Details: Ophthalmic surgery, lasers & imaging, Vol.42(4), pp.292-296
Publisher: United States
DOI: 10.3928/15428877-20110603-04
PMID: 21800802
ISSN: 1542-8877
eISSN: 1938-2375
Language: English
Date published: 07/2011
Academic Unit: Stead Family Department of Pediatrics; Pathology; Ophthalmology and Visual Sciences
Record Identifier: 9983979993102771

Metrics

24 Record Views

27 Times Cited - Web of Science

See more details