Journal article
Vaccination Serology Status and Cardiovascular Mortality: Insight from NHANES III and Continuous NHANES
Postgraduate medicine, Vol.127(6), pp.561-564
11/02/2015
DOI: 10.1080/00325481.2015.1064300
PMID: 26174358
Abstract
Objective. Prior studies have described a negative relationship between influenza vaccination and recurrence of cardiovascular (CV) events. However, due to lack of any prior studies, we evaluated and attempted to define the relationship between non-influenza vaccines and CV mortality. Methods: We used the National Health and Nutrition Examination Survey III (NHANES III-1988-1994, n = 19,215) and Continuous NHANES (1999-2004, n > 17,000), which includes oral surveys and general examination. It was designed to assess the demographic, socioeconomic, dietary, and overall health status of a nationally representative sample in non-institutionalized patients from all 50 states in the USA. Cox proportional hazard regression modeling was used to calculate the hazard ratio of CV mortality, and multivariate models were built for the individual seropositive vaccination titers as well as after creating a combined vaccination variable. Results. A total of >35,000 subjects (>18 years old) have been identified for analysis. Multivariate analysis from NHANES III and continuous NHANES did not show any influence of individual seroprotective titers of routine vaccinations on CV mortality. The combined effect of vaccination in NHANES III data did not show any protective effect of three or more positive vaccination titers (odds ratio = 0.94, p = 0.6) or all four positive vaccination titers (odds ratio = 0.93, p = 0.6) with two or less positive vaccination titers as the referent group. Conclusion. Effect on non-influenza vaccinations in preventing CV mortality seems to be unclear.
Details
- Title: Subtitle
- Vaccination Serology Status and Cardiovascular Mortality: Insight from NHANES III and Continuous NHANES
- Creators
- Ankit Chothani - MedStar Washington Hospital CenterNeeraj Shah - Staten Island University HospitalNileshkumar J Patel - Staten Island University HospitalAbhishek Deshmukh - Mayo ClinicVikas Singh - University of Miami Miller School of MedicineNilay Patel - Saint Peter's University HospitalSidakpal S Panaich - Detroit Medical CenterShilpkumar Arora - Mount Sinai St. Luke's RooseveltAchint Patel - Icahn School of Medicine at Mount SinaiChirag Savani - New York Medical CollegeBadal Thakkar - Tulane University School of Public Health & Tropical MedicineParth Bhatt - Tulane University School of Public Health & Tropical MedicineMauricio G Cohen - University of Miami Miller School of MedicineCindy Grines - Detroit Medical CenterJohn K Forrest - Yale School of MedicineApurva O Badheka - Yale School of Medicine
- Resource Type
- Journal article
- Publication Details
- Postgraduate medicine, Vol.127(6), pp.561-564
- Publisher
- Informa Healthcare
- DOI
- 10.1080/00325481.2015.1064300
- PMID
- 26174358
- ISSN
- 0032-5481
- eISSN
- 1941-9260
- Language
- English
- Date published
- 11/02/2015
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984094349002771
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