Journal article
Vaccine immunotherapy for prostate cancer: from mice to men
Immunologic research, Vol.59(1), pp.229-235
08/2014
DOI: 10.1007/s12026-014-8531-2
PMID: 24847764
Abstract
Preclinical studies demonstrated the ability of an adenovirus/PSA (Ad/PSA) vaccine to induce strong anti-PSA immune responses, and these responses were capable of destroying prostate-specific antigen (PSA)-secreting mouse prostate tumors. A series of preclinical studies have demonstrated the superiority of the Ad/PSA vaccine to other PSA vaccines for the induction of anti-PSA immune responses, the ability of Ad/PSA vaccination combined with cytokine gene therapy and the TLR9 agonist CpG to enhance the anti-prostate tumor immunotherapy, and the reduction of negative regulatory elements when the vaccine was combined with 5-fluoruracil administration. A phase I clinical trial of the Ad/PSA vaccine in men with metastatic castrate-resistant prostate cancer demonstrated the safety of the vaccine even at the highest single dose permitted by the FDA. Currently, a phase II trial of the Ad/PSA vaccine is underway treating patients in two protocols. Thus far 81 patients have been enrolled and vaccinated. Early results from the patients evaluated to date demonstrated the induction of anti-PSA T cell responses, and the majority of patients evaluated at this time had demonstrated an increase in PSA doubling times.
Details
- Title: Subtitle
- Vaccine immunotherapy for prostate cancer: from mice to men
- Creators
- David Lubaroff - Holden Comprehensive Cancer Center University of Iowa Iowa City IA 52242 USADaniel Vaena - Department of Veterans Affairs Medical Center Iowa City IA 52240 USAJames Brown - Department of Veterans Affairs Medical Center Iowa City IA 52240 USAPamela Zehr - Holden Comprehensive Cancer Center University of Iowa Iowa City IA 52242 USAKaren Griffith - Department of Veterans Affairs Medical Center Iowa City IA 52240 USAErica Brown - Department of Urology University of Iowa 375 Newton Road Iowa City IA 52242 USAJulie Eastman - Department of Veterans Affairs Medical Center Iowa City IA 52240 USAKenneth Nepple - Department of Veterans Affairs Medical Center Iowa City IA 52240 USAAmbika Kattula - Department of Urology University of Iowa 375 Newton Road Iowa City IA 52242 USARichard Williams - Holden Comprehensive Cancer Center University of Iowa Iowa City IA 52242 USA
- Contributors
- Gail A Bishop (Editor)
- Resource Type
- Journal article
- Publication Details
- Immunologic research, Vol.59(1), pp.229-235
- Publisher
- Springer US; New York
- DOI
- 10.1007/s12026-014-8531-2
- PMID
- 24847764
- ISSN
- 0257-277X
- eISSN
- 1559-0755
- Language
- English
- Date published
- 08/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Microbiology and Immunology; President; Fraternal Order of Eagles Diabetes Research Center; Urology; Internal Medicine
- Record Identifier
- 9984051579302771
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