Journal article
Validation of a Deficit-Accumulation Frailty Index in the ASPirin in Reducing Events in the Elderly Study and Its Predictive Capacity for Disability-Free Survival
The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.77(1), pp.19-26
01/07/2022
DOI: 10.1093/gerona/glab225
PMCID: PMC8751791
PMID: 34338761
Abstract
Frailty is a state of heightened vulnerability and susceptibility to physiologic stressors that increases with age. It has shown increasing utility in predicting a range of adverse health outcomes. Here, we characterize a 67-item deficit-accumulation frailty index (FI) in 19 110 community-dwelling individuals in the ASPirin in Reducing Events in the Elderly clinical trial. Participants aged 65-98 years were recruited from the United States and Australia and were without diagnosed dementia and cardiovascular disease, and major physical disability. The median FI score was .10 (interquartile range: .07-.14) at baseline, and the prevalence of frailty (FI > .21) increased from 8.1% to 17.4% after 6 years. FI was positively associated with age, and women had significantly higher scores than men at all ages. The FI was negatively correlated with gait speed (r = -.31) and grip strength (r = -.46), and strongly associated with a modified Fried's frailty phenotype (p < .0001, for all comparisons). Frailty was associated with the primary composite outcome capturing independent life lived free of major disability and dementia, and increased the rate of persistent physical disability (hazard ratio: 21.3, 95% confidence interval: 15.6-28.9). It added significantly to the predictive capacity of these outcomes above age, sex, and ethnicity alone. The FI is thus a useful biomarker of aging even among relatively healthy older individuals and provides important information about an individual's vulnerability to and risk of disease.
Details
- Title: Subtitle
- Validation of a Deficit-Accumulation Frailty Index in the ASPirin in Reducing Events in the Elderly Study and Its Predictive Capacity for Disability-Free Survival
- Creators
- Joanne Ryan - Monash UniversitySara Espinoza - The University of Texas Health Science Center at San AntonioMichael E Ernst - University of IowaA R M Saifuddin Ekram - Monash UniversityRory Wolfe - Monash UniversityAnne M Murray - Berman Center for Outcomes and Clinical ResearchRaj C Shah - Rush University Medical CenterSuzanne G Orchard - Monash UniversitySharyn Fitzgerald - Monash UniversityLawrence J Beilin - Royal Perth HospitalStephanie A Ward - Monash UniversityJeff D Williamson - Wake Forest UniversityAnne B Newman - University of PittsburghJohn J McNeil - Monash UniversityRobyn L Woods - Monash UniversityASPREE Investigator Group
- Resource Type
- Journal article
- Publication Details
- The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.77(1), pp.19-26
- DOI
- 10.1093/gerona/glab225
- PMID
- 34338761
- PMCID
- PMC8751791
- ISSN
- 1079-5006
- eISSN
- 1758-535X
- Grant note
- U19 AG062682 / NIA NIH HHS U01AG029824 / NIH HHS
- Language
- English
- Date published
- 01/07/2022
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984297453902771
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