Journal article
Validation of a semi-automatic software for optical coherence tomography - analysis in heart transplanted patients
The international journal of cardiovascular imaging, Vol.39(2), pp.257-268
2023
DOI: 10.1007/s10554-022-02722-9
PMCID: PMC10519345
PMID: 36109445
Abstract
Optical Coherence Tomography (OCT) is an intravascular imaging modality enabling detailed evaluation of cardiac allograft vasculopathy (CAV) after heart transplantation (HTx). However, its clinical application remains hampered by time-consuming manual quantitative analysis. We aimed to validate a semi-automated quantitative OCT analysis software (Iowa Coronary Wall Analyzer, ICWA-OCT) to improve OCT-analysis in HTx patients. 23 patients underwent OCT evaluation of all three major coronary arteries at 3 months (3M) and 12 months (12M) after HTx. We analyzed OCT recordings using the semiautomatic software and compared results with measurements from a validated manual software. For semi-automated analysis, 31,228 frames from 114 vessels were available. The validation was based on a subset of 4287 matched frames. We applied mixed model statistics to accommodate the multilevel data structure with method as a fixed effect. Lumen (minimum, mean, maximum) and media (mean, maximum) metrics showed no significant differences. Mean and maximum intima area were underestimated by the semi-automated method (β-methodmean = − 0.289 mm2, p < 0.01; β-methodmax = − 0.695 mm2, p < 0.01). Bland–Altman analyses showed increasing semi-automatic underestimation of intima measurements with increasing intimal extent. Comparing 3M to 12M progression between methods, mean intimal area showed minor underestimation (β-methodmean = − 1.03 mm2, p = 0.04). Lumen and media metrics showed excellent agreement between the manual and semi-automated method. Intima metrics and progressions from 3M to 12M were slightly underestimated by the semi-automated OCT software with unknown clinical relevance. The semi-automated software has the future potential to provide robust and time-saving evaluation of CAV progression.
Details
- Title: Subtitle
- Validation of a semi-automatic software for optical coherence tomography - analysis in heart transplanted patients
- Creators
- Niels Møller JensenZhi ChenTor Skibsted ClemmensenOmeed NeghabatEmil Nielsen HolckMichal PazdernikLone Juul Hune MogensenAndreas WahleMilan SonkaHans Eiskjær
- Resource Type
- Journal article
- Publication Details
- The international journal of cardiovascular imaging, Vol.39(2), pp.257-268
- DOI
- 10.1007/s10554-022-02722-9
- PMID
- 36109445
- PMCID
- PMC10519345
- NLM abbreviation
- Int J Cardiovasc Imaging
- ISSN
- 1569-5794
- eISSN
- 1875-8312
- Language
- English
- Electronic publication date
- 09/15/2022
- Date published
- 2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984296998802771
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