Journal article
Validation of in vivo myocardial strain measurement by magnetic resonance tagging with sonomicrometry
Journal of the American College of Cardiology, Vol.38(2), pp.555-561
2001
DOI: 10.1016/S0735-1097(01)01397-3
PMID: 11499752
Abstract
OBJECTIVES
This study was designed to validate strain measurements obtained using magnetic resonance tagging with spatial modulation of magnetization (SPAMM). We compared circumferential segment shortening measurements (%S) obtained using SPAMM to sonomicrometry %S in a canine model with (n = 28) and without (n = 3) coronary artery ligation
.
BACKGROUND
Magnetic resonance tagging enables noninvasive measurement of myocardial strain, but such strain measurements have not yet been validated in vivo.
METHODS
Circumferential sonomicrometry crystal pairs were placed in apical myocardium at ischemic risk in ligation studies and in adjacent and remote myocardium. The %S was obtained from closely juxtaposed sonomicrometry and SPAMM sites.
RESULTS
Paired data were available from 19 of 31 studies. Both methods distinguished remote from ischemic function effectively (p = 0.014 for SPAMM and p = 0.002 for sonomicrometry). SPAMM %S was similar to sonomicrometry %S in ischemic myocardium (2 ± 3 vs. 0 ± 3, p = 0.067) but was slightly higher than sonomicrometry %S in remote myocardium (11 ± 10 vs. 7 ± 5, p = 0.033). End-systolic (n = 30) and late systolic (n = 34) SPAMM %S correlated well with sonomicrometry %S (r = 0.84, p < 0.0001 and r = 0.88, p < 0.0001).
CONCLUSIONS
Magnetic resonance tagging using SPAMM can quantitate myocardial strain in ischemic and remote myocardium. This study validates its application in scientific investigation and clinical assessment of patients with myocardial ischemia.
Details
- Title: Subtitle
- Validation of in vivo myocardial strain measurement by magnetic resonance tagging with sonomicrometry
- Creators
- Susan B Yeon - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USANathaniel Reichek - Division of Cardiology, Department of Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania, USABarbara A Tallant - Cardiovascular Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USAJoão A.C Lima - Cardiology Division, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USALinda P Calhoun - Cardiovascular Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USANeil R Clark - Cardiovascular Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USAEric A Hoffman - Department of Radiology, University of Iowa College of Medicine, Iowa City, Iowa, USAKalon K.L Ho - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USALeon Axel - Cardiovascular Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Resource Type
- Journal article
- Publication Details
- Journal of the American College of Cardiology, Vol.38(2), pp.555-561
- DOI
- 10.1016/S0735-1097(01)01397-3
- PMID
- 11499752
- NLM abbreviation
- J Am Coll Cardiol
- ISSN
- 0735-1097
- eISSN
- 1558-3597
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2001
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051881302771
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