Validation of rapid HIV antibody tests in 5 African countries

Estelle M Piwowar-Manning; Nancy B Tustin; Physiwell Sikateyo; Debbie Kamwendo; Chifundo Chipungu; Rashika Maharaj; Jabulani Mushanyu; Barbra A Richardson; Sharon Hillier; J Brooks Jackson

doi:10.1177/1545109710368151

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Validation of rapid HIV antibody tests in 5 African countries

Journal article

Open access

Validation of rapid HIV antibody tests in 5 African countries

Estelle M Piwowar-Manning, Nancy B Tustin, Physiwell Sikateyo, Debbie Kamwendo, Chifundo Chipungu, Rashika Maharaj, Jabulani Mushanyu, Barbra A Richardson, Sharon Hillier and J Brooks Jackson

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002), Vol.9(3), pp.170-172

05/2010

DOI: 10.1177/1545109710368151

PMCID: PMC2989535

PMID: 20530471

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https://doi.org/10.1177/1545109710368151View

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Abstract

The sensitivity and specificity of 3 rapid HIV antibody tests were assessed at 5 clinical trial sites in Africa and 1 site in the United States using a minimum of 100 HIV antibody positive samples and 100 HIV antibody negative samples at each site. The overall sensitivity and specificity for the OraSure OraQuick, Abbott Determine, and Trinity Unigold tests were 99.3%, 99.8%, and 98.5%, respectively, and 99.3%, 99.4%, and 99.5%, respectively. There were no instances at any site in which false-negative or false-positive results were obtained for the same sample on more than 1 rapid test kit. The results of this study provide assurance that for these diverse sites in Africa, the accuracy of these kits is quite good. Given the excellent accuracy, relatively fast turnaround time, and minimal infrastructure required, these rapid tests for HIV antibody provide a very attractive and accurate testing format.

Africa

HIV Antibodies - blood

HIV Infections - diagnosis

Humans

Reagent Kits, Diagnostic

Sensitivity and Specificity

Details

Title: Subtitle: Validation of rapid HIV antibody tests in 5 African countries
Creators: Estelle M Piwowar-Manning - Johns Hopkins University, Department of Pathology, Baltimore, MD, USA. epiwowa@jhmi.edu
Nancy B Tustin
Physiwell Sikateyo
Debbie Kamwendo
Chifundo Chipungu
Rashika Maharaj
Jabulani Mushanyu
Barbra A Richardson
Sharon Hillier
J Brooks Jackson
Resource Type: Journal article
Publication Details: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002), Vol.9(3), pp.170-172
DOI: 10.1177/1545109710368151
PMID: 20530471
PMCID: PMC2989535
NLM abbreviation: J Int Assoc Physicians AIDS Care (Chic)
ISSN: 1545-1097
eISSN: 1557-0886
Publisher: United States
Grant note: U01 AI068613 / NIAID NIH HHS U01 AI046749 / NIAID NIH HHS U01 AI046749-05 / NIAID NIH HHS 1U01AI068613 / NIAID NIH HHS U01 AI068613-04 / NIAID NIH HHS
Language: English
Date published: 05/2010
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984047794402771

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