Journal article
Validation of the UNC OCT index for the diagnosis of early glaucoma
Translational Vision Science and Technology, Vol.7(2), pp.16-16
2018
DOI: 10.1167/tvst.7.2.16
PMCID: PMC5886105
PMID: 29629238
Abstract
Purpose: To independently validate the performance of the University of North Carolina Optical Coherence Tomography (UNC OCT) Index in diagnosing and predicting early glaucoma.Methods: Data of 118 normal subjects (118 eyes) and 96 subjects (96 eyes) with early glaucoma defined as visual field mean deviation (MD) greater than -4 decibels (dB), aged 40 to 80 years, and who were enrolled in the Full-Threshold Testing Size III, V, VI comparison study were used in this study. CIRRUS OCT average and quadrants' retinal nerve fiber layer (RNFL); optic disc vertical cup-to-disc ratio (VCDR), cup-to-disc area ratio, and rim area; and average, minimum, and six sectoral ganglion cell-inner plexiform layer (GCIPL) measurements were run through the UNC OCT Index algorithm. Area under the receiver operating characteristic curve (AUC) and sensitivities at 95% and 99% specificity were calculated and compared between single parameters and the UNC OCT Index.Results: Mean age was 60.1 ± 11.0 years for normal subjects and 66.5 ± 8.1 years for glaucoma patients (P < 0.001). MD was 0.29 ± 1.04 dB and -1.30 ± 1.35 dB in normal and glaucomatous eyes (P < 0.001), respectively. The AUC of the UNC OCT Index was 0.96. The best single metrics when compared to the UNC OCT Index were VCDR (0.93, P = 0.054), average RNFL (0.92, P = 0.014), and minimum GCIPL (0.91, P = 0.009). The sensitivities at 95% and 99% specificity were 85.4% and 76.0% (UNC OCT Index), 71.9% and 62.5% (VCDR, all P < 0.001), 64.6% and 53.1% (average RNFL, all P < 0.001), and 66.7% and 58.3% (minimum GCIPL, all P < 0.001), respectively.Conclusions: The findings confirm that the UNC OCT Index may provide improved diagnostic perforce over that of single OCT parameters and may be a good tool for detection of early glaucoma.Translational Relevance: The UNC OCT Index algorithm may be incorporated easily into routine clinical practice and be useful for detecting early glaucoma.
Details
- Title: Subtitle
- Validation of the UNC OCT index for the diagnosis of early glaucoma
- Creators
- Jean Claude MwanzaDonald L BudenzGary LeeThomas M CallanJoshua L WarrenMichael WallPaul H ArtesJohn G Flanagan
- Resource Type
- Journal article
- Publication Details
- Translational Vision Science and Technology, Vol.7(2), pp.16-16
- DOI
- 10.1167/tvst.7.2.16
- PMID
- 29629238
- PMCID
- PMC5886105
- ISSN
- 2164-2591
- eISSN
- 2164-2591
- Language
- English
- Date published
- 2018
- Academic Unit
- Neurology; Ophthalmology and Visual Sciences
- Record Identifier
- 9983979995602771
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