Journal article
Validity of diabetes self-reports in the Women's Health Initiative: comparison with medication inventories and fasting glucose measurements
Clinical trials (London, England), Vol.5(3), pp.240-247
2008
DOI: 10.1177/1740774508091749
PMCID: PMC2757268
PMID: 18559413
Abstract
Although diabetes is conveniently assessed by self-report, few validation studies have been performed. Therefore, we studied whether self-report of prevalent and incident diabetes in Women's Health Initiative (WHI) participants was concordant with other diagnostic evidence of diabetes.
A total of 161 808 postmenopausal women aged 50-79 were enrolled at 40 clinical centers in the U.S. in 1993-1998 and followed prospectively. At baseline, prevalent medication treated diabetes was defined as a self-report of physician diagnosis and treatment with insulin or oral antidiabetic drugs. During followup, incident treated diabetes was defined as a self-report of a new physician diagnosis of diabetes treated with insulin or oral drugs. Diabetes self-reports were compared with medication inventories and fasting glucose levels at baseline and during follow-up.
At baseline, self-reported treated diabetes was concordant with the medication inventory in 79% of clinical trial, and 77% of observational study participants. Self-reported incident treated diabetes was concordant with the medication inventory in 78% between baseline and Year 1 in the clinical trials, in 62% between Year 1 and Year 3 in the clinical trials, and in 72% between baseline and Year 3 in the observational study. Over similar periods, 99.9% of those who did not report treated diabetes had no oral antidiabetic drugs or insulin in the medication inventory. At baseline, about 3% not reporting diabetes had fasting glucose >126 mg/dl, and 88% of these subjects subsequently reported treated diabetes during 6.9 years of follow-up.
Incident self-reported diabetes treated by lifestyle alone was not determined in WHI. Medication inventories may have been incomplete and fasting glucose may have been lowered by treatment; therefore, concordance with self-reported treatment or fasting glucose > or = 126 may have been underestimated.
In the WHI, self-reported prevalent and incident diabetes was consistent with medication inventories, and a high proportion of those with undiagnosed diabetes subsequently reported diabetes treatment. Self-reports of ;treated diabetes' are sufficiently accurate to allow use in epidemiologic studies.
Details
- Title: Subtitle
- Validity of diabetes self-reports in the Women's Health Initiative: comparison with medication inventories and fasting glucose measurements
- Creators
- Karen L Margolis - HealthPartners Research Foundation, Minneapolis, MN 55440-1524, USA, KarenL.Margolis@HealthPartners.ComLihong QiRobert BrzyskiDenise E BondsBarbara V HowardSarah KempainenSimin LiuJennifer G RobinsonMonika M SaffordLesley T TinkerLawrence S PhillipsWomen Health Initiative Investigators
- Resource Type
- Journal article
- Publication Details
- Clinical trials (London, England), Vol.5(3), pp.240-247
- DOI
- 10.1177/1740774508091749
- PMID
- 18559413
- PMCID
- PMC2757268
- NLM abbreviation
- Clin Trials
- ISSN
- 1740-7745
- eISSN
- 1740-7753
- Publisher
- England
- Grant note
- N01WH32122 / WHI NIH HHS N01WH32100-2 / WHI NIH HHS N01WH32118-32119 / WHI NIH HHS N01WH32115 / WHI NIH HHS N01WH32108-9 / WHI NIH HHS N01WH24152 / WHI NIH HHS N01WH42129-32 / WHI NIH HHS N01WH42107-26 / WHI NIH HHS R01 DK062290 / NIDDK NIH HHS N01WH44221 / WHI NIH HHS N01WH22110 / WHI NIH HHS R01 DK062290-05 / NIDDK NIH HHS N01WH32111-13 / WHI NIH HHS N01WH32105-6 / WHI NIH HHS
- Language
- English
- Date published
- 2008
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983995154602771
Metrics
42 Record Views