Journal article
Vancomycin Derivatives That Inhibit Peptidoglycan Biosynthesis Without Binding d -Ala- d -Ala
Science (American Association for the Advancement of Science), Vol.284(5413), pp.507-511
04/16/1999
DOI: 10.1126/science.284.5413.507
PMID: 10205063
Abstract
Vancomycin is an important drug for the treatment of Gram-positive bacterial infections. Resistance to vancomycin has begun to appear, posing a serious public health threat. Vancomycin analogs containing modified carbohydrates are very active against resistant microorganisms. Results presented here show that these carbohydrate derivatives operate by a different mechanism than vancomycin; moreover, peptide binding is not required for activity. It is proposed that carbohydrate-modified vancomycin compounds are effective against resistant bacteria because they interact directly with bacterial proteins involved in the transglycosylation step of cell wall biosynthesis. These results suggest new strategies for designing glycopeptide antibiotics that overcome bacterial resistance.
Details
- Title: Subtitle
- Vancomycin Derivatives That Inhibit Peptidoglycan Biosynthesis Without Binding d -Ala- d -Ala
- Creators
- Min Ge - Princeton UniversityZhong Chen - Princeton UniversityH. RussellJoyce Kohler - MSDLynn L. Silver - MSDRobert Kerns - Princeton UniversitySeketsu Fukuzawa - Princeton UniversityChristopher Thompson - Princeton UniversityDaniel Kahne - Princeton University
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.284(5413), pp.507-511
- DOI
- 10.1126/science.284.5413.507
- PMID
- 10205063
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 04/16/1999
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984365885102771
Metrics
4 Record Views