Journal article
Vancomycin-resistant enterococcal bacteremia: natural history and attributable mortality
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol.23(6), pp.1234-1239
12/1996
DOI: 10.1093/clinids/23.6.1234
PMID: 8953064
Abstract
Previous studies have shown that bacteremia due to vancomycin-resistant Enterococcus species (VRE) is associated with mortality of 17%-100%, but comorbid conditions may have confounded the estimates. We designed a historical cohort study to determine the mortality attributable to VRE bacteremia. Twenty-seven patients with VRE bacteremia were identified as cases. Within 7 days of the onset of bacteremia, severe sepsis developed in 12 patients (44%) and septic shock developed in 10 (37%). Case patients were closely matched to control patients without VRE bacteremia (1:1) by time of hospitalization, duration of exposure, underlying disease, age, gender, and surgical procedure. The mortality was 67% among cases and 30% among matched controls (P = 0.1). Thus, the mortality attributable to VRE bacteremia was 37% (95% confidence interval [CI], 10%-64%) and the risk ratio for death was 2.3 [CI, 1.2-4.1). We conclude that VRE bacteremia is associated with high rates of severe sepsis and septic shock. The attributable mortality approaches 40%, and patients who have VRE bacteremia are twice as likely to die than closely matched controls.
Details
- Title: Subtitle
- Vancomycin-resistant enterococcal bacteremia: natural history and attributable mortality
- Creators
- Michael B Edmund - Division of Quality Health Care, Medical College of Virginia Commonwealth University, Richmond 23298-0509, USA. MEDMOND@Gems.VCU.EDUJanis F OberJeffrey D DawsonDavid L WeinbaumRichard P Wenzel
- Resource Type
- Journal article
- Publication Details
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol.23(6), pp.1234-1239
- DOI
- 10.1093/clinids/23.6.1234
- PMID
- 8953064
- NLM abbreviation
- Clin Infect Dis
- ISSN
- 1058-4838
- eISSN
- 1537-6591
- Publisher
- United States
- Language
- English
- Date published
- 12/1996
- Academic Unit
- Public Health Administration; Infectious Diseases; Biostatistics; Internal Medicine
- Record Identifier
- 9983905523002771
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