Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type 1-infected patients with 200-500 CD4 cells/mm(3) (ACTG 175). AIDS Clinical Trials Group Protocol 175 Team

Janet L Lathey; Michael D Hughes; Susan A Fiscus; Timothy Pi; J Brooks Jackson; Suraiya Rasheed; Tarek Elbeik; Richard Reichman; Anthony Japour; Richard T D'Aquila; Walter Scott; Brigitte P Griffith; Scott M Hammer; David A Katzenstein

doi:10.1086/514250

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Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type 1-infected patients with 200-500 CD4 cells/mm(3) (ACTG 175). AIDS Clinical Trials Group Protocol 175 Team

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Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type 1-infected patients with 200-500 CD4 cells/mm(3) (ACTG 175). AIDS Clinical Trials Group Protocol 175 Team

Janet L Lathey, Michael D Hughes, Susan A Fiscus, Timothy Pi, J Brooks Jackson, Suraiya Rasheed, Tarek Elbeik, Richard Reichman, Anthony Japour, Richard T D'Aquila, …

The Journal of infectious diseases, Vol.177(3), pp.617-624

03/1998

DOI: 10.1086/514250

PMID: 9498440

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Abstract

Virologic measurements are increasingly used to evaluate prognosis and treatment responses in human immunodeficiency virus (HIV) type 1 infection. Markers of HIV-1 replication, including infectious HIV-1 titer from peripheral blood mononuclear cells, serum HIV-1 p24 antigen, plasma HIV-1 RNA, CD4 cell numbers, and viral syncytium-inducing (SI) phenotype, were determined in 391 virology substudy participants in AIDS Clinical Trials Group study 175. The subjects had 200-500 CD4 cells/mm3. All markers of viral replication significantly correlated with one another and were inversely related to CD4 cell number. Disease progression to an AIDS-defining event or death or loss of >50% of CD4 cells was associated with infectious HIV-1 titer (P < .001), HIV-1 RNA (P < .001), and HIV-1 p24 antigen (P = .007). In multivariate proportional hazards models, p24 antigen was never significant when HIV-1 RNA level was included. In a model containing infectious HIV-1 titer (P = .038), HIV-1 RNA (P < .001), SI phenotype (P < .001), and CD4 cell number (P = .18), only the virologic parameters remained significantly associated with progression.

HIV-1

Multivariate Analysis

Predictive Value of Tests

HIV Infections - virology

Humans

Proportional Hazards Models

Cytopathogenic Effect, Viral

RNA, Viral - blood

CD4 Lymphocyte Count

Viral Load

HIV Infections - immunology

HIV Infections - mortality

HIV Core Protein p24 - blood

Details

Title: Subtitle: Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type 1-infected patients with 200-500 CD4 cells/mm(3) (ACTG 175). AIDS Clinical Trials Group Protocol 175 Team
Creators: Janet L Lathey - Department of Pediatrics, University of California, San Diego, La Jolla 92093-0672, USA. jlathey@ucsd.edu
Michael D Hughes
Susan A Fiscus
Timothy Pi
J Brooks Jackson
Suraiya Rasheed
Tarek Elbeik
Richard Reichman
Anthony Japour
Richard T D'Aquila
Walter Scott
Brigitte P Griffith
Scott M Hammer
David A Katzenstein
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.177(3), pp.617-624
DOI: 10.1086/514250
PMID: 9498440
NLM abbreviation: J Infect Dis
ISSN: 0022-1899
eISSN: 1537-6613
Publisher: United States
Grant note: AI-38858 / NIAID NIH HHS AI-27670 / NIAID NIH HHS AI-36214 / NIAID NIH HHS
Language: English
Date published: 03/1998
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984047685202771

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