Journal article
Variability in PCB and OH-PCB serum levels in children and their mothers in urban and rural U.S. communities
Environmental science & technology, Vol.48(22), pp.13459-13467
11/18/2014
DOI: 10.1021/es502490w
PMCID: PMC4238695
PMID: 25300024
Abstract
Environmental exposures that affect accumulation of polychlorinated biphenyls (PCBs) in humans are complex and not fully understood. One challenge in linking environmental exposure to accumulation is determining variability of PCB concentrations in samples collected from the same person at different times. We hypothesized that PCBs in human blood serum are consistent from year to year in people who live in the same environment between sampling. We analyzed blood serum from children and their mothers from urban and rural U.S. communities (n = 200) for all 209 PCBs (median ∑PCBs = 45 ng/g lw) and 12 hydroxylated PCBs (median ∑OH-PCBs = 0.09 ng/g fw). A subset of these participants (n = 155) also had blood PCB and OH-PCB concentrations analyzed during the previous calendar year. Although many participants had similar levels of PCBs and OH-PCBs in their blood from one year to the next, some participants had surprisingly different levels. Year-to-year variability in ∑PCBs ranged from -87% to 567% and in ∑OH-PCBs ranged from -51 to 358% (5th-95th percentile). This is the first study to report variability of all PCBs and major metabolites in two generations of people and suggests short-term exposures to PCBs may be a significant component of what is measured in human serum.
Details
- Title: Subtitle
- Variability in PCB and OH-PCB serum levels in children and their mothers in urban and rural U.S. communities
- Creators
- Rachel F Marek - Department of Civil & Environmental Engineering, The University of Iowa , Iowa City, Iowa 52242, United StatesPeter S ThorneJeanne DeWallKeri C Hornbuckle
- Resource Type
- Journal article
- Publication Details
- Environmental science & technology, Vol.48(22), pp.13459-13467
- Publisher
- United States
- DOI
- 10.1021/es502490w
- PMID
- 25300024
- PMCID
- PMC4238695
- ISSN
- 0013-936X
- eISSN
- 1520-5851
- Grant note
- P30 ES005605 / NIEHS NIH HHS NIH P42ES013661 / NIEHS NIH HHS P30ES005605 / NIEHS NIH HHS P42 ES013661 / NIEHS NIH HHS
- Language
- English
- Date published
- 11/18/2014
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health; IIHR--Hydroscience and Engineering; Iowa Superfund Research Program
- Record Identifier
- 9983806366902771
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