Journal article
Variability of the Polymerase Gene (NS5B) in Hepatitis C Virus-Infected Women
Journal of clinical microbiology, Vol.48(11), pp.4256-4259
11/01/2010
DOI: 10.1128/JCM.01613-10
PMCID: PMC3020841
PMID: 20810773
Abstract
There are limited data on diversity within the hepatitis C virus polymerase (NS5B). In concordance with its key functional role during the life cycle, NS5B intrapatient variability was low. Moreover, differences between NS5B nonsynonymous (
dN
) and synonymous (
dS
) mutation rates (
dN
−
dS
) were positively correlated with CD4 cell count, while nonsynonymous mutations were strongly correlated with reduced replication
in vivo
.
Details
- Title: Subtitle
- Variability of the Polymerase Gene (NS5B) in Hepatitis C Virus-Infected Women
- Creators
- Jason T. Blackard - University of Cincinnati Medical CenterGang Ma - University of Cincinnati Medical CenterBerkeley N. Limketkai - University of Cincinnati Medical CenterJeffrey A. Welge - University of Cincinnati Medical CenterPeter D. Dryer - University of Cincinnati Medical CenterChristina M. Martin - University of Cincinnati Medical CenterYoichi Hiasa - Ehime UniversityLynn E. Taylor - Miriam HospitalKenneth H. Mayer - Miriam HospitalDenise J. Jamieson - Centers for Disease Control and PreventionKenneth E. Sherman - University of Cincinnati Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of clinical microbiology, Vol.48(11), pp.4256-4259
- Publisher
- American Society for Microbiology (ASM)
- DOI
- 10.1128/JCM.01613-10
- PMID
- 20810773
- PMCID
- PMC3020841
- ISSN
- 0095-1137
- eISSN
- 1098-660X
- Language
- English
- Date published
- 11/01/2010
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446433202771
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