Journal article
Variable Association of Physiologic Changes With Electrographic Seizure-Like Events in Infants Born Preterm
The Journal of pediatrics, Vol.257, pp.113348-113348
06/2023
DOI: 10.1016/j.jpeds.2022.12.044
PMCID: PMC10575679
PMID: 36801212
Abstract
To determine the incidence of seizure-like events in a cohort of infants born preterm as well as the prevalence of associated vital sign changes (heart rate [HR], respiratory rate, and pulse oximetry [SpO2]).
We performed prospective conventional video electroencephalogram monitoring on infants born at 23-30 weeks of gestational age during the first 4 postnatal days. For detected seizure-like events, simultaneously captured vital sign data were analyzed during the pre-event baseline and during the event. Significant vital sign changes were defined as HR or respiratory rate >±2 SD from the infant’s own baseline physiologic mean, derived from a 10-minute interval before the seizure-like event. Significant change in SpO2 was defined as oxygen desaturation during the event with a mean SpO2 <88%.
Our sample included 48 infants with median gestational age of 28 weeks (IQR 26-29) and birth weight of 1125 g (IQR 963-1265). Twelve (25%) infants had seizure-like discharges with a total of 201 events; 83% (10/12) of infants had vital sign changes during these events, and 50% (6/12) had significant vital sign changes during the majority of the seizure-like events. Concurrent HR changes occurred the most frequently.
Individual infant variability was observed in the prevalence of concurrent vital sign changes with electroencephalographic seizure-like events. Physiologic changes associated with preterm electrographic seizure-like events should be investigated further as a potential biomarker to assess the clinical significance of such events in the preterm population.
Details
- Title: Subtitle
- Variable Association of Physiologic Changes With Electrographic Seizure-Like Events in Infants Born Preterm
- Creators
- Stephanie S. Lee - University of IowaNathalie El Ters - Washington University in St. LouisZachary A. Vesoulis - Washington University in St. LouisJohn M. Zempel - Washington University in St. LouisAmit M. Mathur - Saint Louis University
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.257, pp.113348-113348
- DOI
- 10.1016/j.jpeds.2022.12.044
- PMID
- 36801212
- PMCID
- PMC10575679
- NLM abbreviation
- J Pediatr
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Publisher
- Elsevier Inc
- Grant note
- Gerber Foundation (https://doi.org/10.13039/100001130) NS111086 / National Institutes of Health (https://doi.org/10.13039/100000002)
- Language
- English
- Date published
- 06/2023
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984695681102771
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