Variants in Genes Involved in Functional Pathways Associated with Hypertension in African Americans

Maria P. Martinez Cantarin; Adam Ertel; Stephanie Deloach; Paolo Fortina; Kathryn Scott; Trudy L. Burns; Bonita Falkner

doi:10.1111/j.1752-8062.2010.00242.x

Back

Variants in Genes Involved in Functional Pathways Associated with Hypertension in African Americans

Journal article

Open access

Peer reviewed

Variants in Genes Involved in Functional Pathways Associated with Hypertension in African Americans

Maria P. Martinez Cantarin, Adam Ertel, Stephanie Deloach, Paolo Fortina, Kathryn Scott, Trudy L. Burns and Bonita Falkner

Clinical and translational science, Vol.3(6), pp.279-286

12/01/2010

DOI: 10.1111/j.1752-8062.2010.00242.x

PMCID: PMC5439635

PMID: 21167003

Files and links (1)

url

https://doi.org/10.1111/j.1752-8062.2010.00242.xView

Published (Version of record) Open Access

Abstract

Essential hypertension (HBP) is a complex trait with a substantial heritable component. The purpose of this study was to determine if variants in the G‐protein coupled receptor Kinase‐4 ( GRK4 ), nitric oxide synthase‐3 ( NOS3 ), or angiotensin converting enzyme ( ACE ) genes are associated singly or through complex interactions, with HBP in African Americans aged 18–49 years. TaqMan Assays were used for genotyping the GRK4 and NOS3 variants. The ACE I/D variant was obtained by polymerase chain reaction and electrophoresis. Allelic association tests were performed for the five markers using PLINK. Logistic regression models were fitted to investigate associations between HBP status and the genetic markers. Multilocus analyses were also conducted. The study included 173 hypertensives and 239 normotensives, with stratification into obese and nonobese groups. The GRK4 A486V variant was negatively associated with HBP in the nonobese group ( p = 0.048). The TT/CT genotype of GRK4 A486V was associated with decreased risk for HBP relative to the CC genotype after adjusting for age, sex, and body mass index ( p = 0.028). Individuals having at least one NOS3 A allele and GRK4 R65L genotype GG had odds of HBP of 2.97 relative to GG homozygotes for NOS3 and GRK4 R65L. These results show very modest effects and do not fully replicate previous studies. Clin Trans Sci 2010; Volume 3: 279–286

ACE

African Americans

genetic variants

GRK4

hypertension

NOS3

Details

Title: Subtitle: Variants in Genes Involved in Functional Pathways Associated with Hypertension in African Americans
Creators: Maria P. Martinez Cantarin - Thomas Jefferson University
Adam Ertel - Thomas Jefferson University
Stephanie Deloach - Thomas Jefferson University
Paolo Fortina - Thomas Jefferson University
Kathryn Scott - Thomas Jefferson University
Trudy L. Burns - University of Iowa
Bonita Falkner - Thomas Jefferson University
Resource Type: Journal article
Publication Details: Clinical and translational science, Vol.3(6), pp.279-286
DOI: 10.1111/j.1752-8062.2010.00242.x
PMID: 21167003
PMCID: PMC5439635
NLM abbreviation: Clin Transl Sci
ISSN: 1752-8054
eISSN: 1752-8062
Publisher: Blackwell Publishing Inc
Language: English
Date published: 12/01/2010
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984363577602771

Metrics

16 Record Views

22 Times Cited - Web of Science

See more details