Variants in nicotinic receptors and risk for nicotine dependence

Laura Jean Bierut; Jerry A Stitzel; Jen C Wang; Anthony L Hinrichs; Richard A Grucza; Xiaoling Xuei; Nancy L Saccone; Scott F Saccone; Sarah Bertelsen; Louis Fox; William J Horton; Naomi Breslau; John Budde; C Robert Cloninger; Danielle M Dick; Tatiana Foroud; Dorothy Hatsukami; Victor Hesselbrock; Eric O Johnson; John Kramer; Samuel Kuperman; Pamela A F Madden; Kevin Mayo; John  Nurnberger Jr; Ovide Pomerleau; Bernice Porjesz; Oliver Reyes; Marc Schuckit; Gary Swan; Jay A Tischfield; Howard J Edenberg; John P Rice; Alison M Goate

doi:10.1176/appi.ajp.2008.07111711

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Variants in nicotinic receptors and risk for nicotine dependence

Journal article

Peer reviewed

Variants in nicotinic receptors and risk for nicotine dependence

Laura Jean Bierut, Jerry A Stitzel, Jen C Wang, Anthony L Hinrichs, Richard A Grucza, Xiaoling Xuei, Nancy L Saccone, Scott F Saccone, Sarah Bertelsen, Louis Fox, …

The American journal of psychiatry, Vol.165(9), pp.1163-1171

09/2008

DOI: 10.1176/appi.ajp.2008.07111711

PMCID: PMC2574742

PMID: 18519524

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https://soar.suny.edu/bitstream/20.500.12648/8218/1/nihms55336.pdfView

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Abstract

A recent study provisionally identified numerous genetic variants as risk factors for the transition from smoking to the development of nicotine dependence, including an amino acid change in the alpha5 nicotinic cholinergic receptor (CHRNA5). The purpose of this study was to replicate these findings in an independent data set and more thoroughly investigate the role of genetic variation in the cluster of physically linked nicotinic receptors, CHRNA5-CHRNA3-CHRNB4, and the risk of smoking.

Phenotype

Polymerase Chain Reaction

Cell Line

Species Specificity

Humans

Risk Factors

Genotype

DNA Primers - genetics

Nerve Tissue Proteins - genetics

Linkage Disequilibrium

Polymorphism, Single Nucleotide - genetics

Tobacco Use Disorder - genetics

Receptors, Nicotinic - genetics

Details

Title: Subtitle: Variants in nicotinic receptors and risk for nicotine dependence
Creators: Laura Jean Bierut - Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave., St. Louis, MO 63110, USA. bierutl@msnotes.wustl.edu
Jerry A Stitzel
Jen C Wang
Anthony L Hinrichs
Richard A Grucza
Xiaoling Xuei
Nancy L Saccone
Scott F Saccone
Sarah Bertelsen
Louis Fox
William J Horton
Naomi Breslau
John Budde
C Robert Cloninger
Danielle M Dick
Tatiana Foroud
Dorothy Hatsukami
Victor Hesselbrock
Eric O Johnson
John Kramer
Samuel Kuperman
Pamela A F Madden
Kevin Mayo
John Nurnberger Jr
Ovide Pomerleau
Bernice Porjesz
Oliver Reyes
Marc Schuckit
Gary Swan
Jay A Tischfield
Howard J Edenberg
John P Rice
Alison M Goate
Resource Type: Journal article
Publication Details: The American journal of psychiatry, Vol.165(9), pp.1163-1171
DOI: 10.1176/appi.ajp.2008.07111711
PMID: 18519524
PMCID: PMC2574742
NLM abbreviation: Am J Psychiatry
ISSN: 0002-953X
eISSN: 1535-7228
Publisher: United States
Grant note: K02 DA021237 / NIDA NIH HHS K01 DA021237 / NIDA NIH HHS U10 AA008401-19 / NIAAA NIH HHS R01 DA014369 / NIDA NIH HHS R01 DA012854 / NIDA NIH HHS K01 DA015129-05 / NIDA NIH HHS R01 DA014369-05 / NIDA NIH HHS K01 AA015572-02 / NIAAA NIH HHS U10 AA008401 / NIAAA NIH HHS R01 DA02854 / NIDA NIH HHS K01 DA015129 / NIDA NIH HHS K01 AA015572 / NIAAA NIH HHS P01 CA89392 / NCI NIH HHS R01 DA16618 / NIDA NIH HHS U10 AA-008401 / NIAAA NIH HHS P01 CA089392-05 / NCI NIH HHS K01 DA016618-05 / NIDA NIH HHS P01 CA089392 / NCI NIH HHS K01 DA016618 / NIDA NIH HHS R01 DA012854-05 / NIDA NIH HHS
Language: English
Date published: 09/2008
Academic Unit: Psychiatry; Stead Family Department of Pediatrics
Record Identifier: 9984004199302771

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