Journal article
Variants in tamoxifen metabolizing genes: a case-control study of contralateral breast cancer risk in the WECARE study
International journal of molecular epidemiology and genetics, Vol.4(1), pp.35-48
2013
PMCID: PMC3612453
PMID: 23565321
Abstract
Tamoxifen has been shown to greatly reduce risk of recurrence and contralateral breast cancer (CBC). Still, second primary contralateral breast cancer is the most common malignancy to follow a first primary breast cancer. Genetic variants in
CYP2D6
and other drug-metabolizing enzymes that alter the metabolism of tamoxifen may be associated with CBC risk in women who receive the drug. This is the first study to investigate the impact of this variation on risk of CBC in women who receive tamoxifen. From the population-based Women’s Environment Cancer and Radiation Epidemiology (WECARE) Study, we included 624 Caucasian women with CBC (cases) and 1,199 women with unilateral breast cancer (controls) with complete information on tumor characteristics and treatment. Conditional logistic regression was used to assess the risk of CBC associated with 112 single nucleotide polymorphisms (SNPs) in 8 genes involved in the metabolism of tamoxifen among tamoxifen users and non-users. After adjustment for multiple testing, no significant association was observed between any of the genotyped variants and CBC risk in either tamoxifen users or non-users. These results suggest that when using a tagSNP approach, common variants in selected genes involved in the metabolism of tamoxifen are not associated with risk of CBC among women treated with the drug.
Details
- Title: Subtitle
- Variants in tamoxifen metabolizing genes: a case-control study of contralateral breast cancer risk in the WECARE study
- Creators
- Jennifer D Brooks - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer CenterSharon N Teraoka - University of Florida Genetics Institute and Department of Pathology, Immunology and Laboratory Medicine, University of FloridaKathleen E Malone - Program in Epidemiology, Division of Public Health Science, Fred Hutchinson Cancer Research CenterRobert W Haile - Stanford School of Medicine, Department of Medicine, Division of OncologyLeslie Bernstein - Department of Population Sciences, Beckman Research Institute of the City of HopeCharles F Lynch - Department of Epidemiology, The University of Iowa College of Public HealthLene Mellemkjær - Research Department II, Institute of Cancer Epidemiology, Danish Cancer SocietyDavid J Duggan - Genetic Basis of Human Disease Division, Translational Genomic Research InstituteAnne S Reiner - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer CenterPatrick Concannon - University of Florida Genetics Institute and Department of Pathology, Immunology and Laboratory Medicine, University of FloridaKatherine Schiermeyer - Department of Biochemistry and Molecular Genetics, University of VirginiaJuan Pablo Lewinger - Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern CaliforniaJonine L Bernstein - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer CenterWECARE Study Collaborative GroupJane C Figueiredo - Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
- Resource Type
- Journal article
- Publication Details
- International journal of molecular epidemiology and genetics, Vol.4(1), pp.35-48
- Publisher
- e-Century Publishing Corporation
- PMID
- 23565321
- PMCID
- PMC3612453
- ISSN
- 1948-1756
- eISSN
- 1948-1756
- Language
- English
- Date published
- 2013
- Academic Unit
- Epidemiology
- Record Identifier
- 9983996094902771
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