Variation in susceptibility of bloodstream isolates of Candida glabrata to fluconazole according to patient age and geographic location

M A Pfaller; S A Messer; L Boyken; S Tendolkar; R J Hollis; D J Diekema

doi:10.1128/JCM.41.5.2176-2179.2003

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Variation in susceptibility of bloodstream isolates of Candida glabrata to fluconazole according to patient age and geographic location

Journal article

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Peer reviewed

Variation in susceptibility of bloodstream isolates of Candida glabrata to fluconazole according to patient age and geographic location

M A Pfaller, S A Messer, L Boyken, S Tendolkar, R J Hollis and D J Diekema

Journal of clinical microbiology, Vol.41(5), pp.2176-2179

05/2003

DOI: 10.1128/JCM.41.5.2176-2179.2003

PMCID: PMC154732

PMID: 12734273

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Abstract

We examined the susceptibilities to fluconazole of 559 bloodstream infection isolates of Candida glabrata and grouped the isolates by patient age and geographic location within the United States. Susceptibility of C. glabrata to fluconazole was lowest in the Pacific (44%) and East South Central (47%) regions and was highest in the West South Central region (82%) (regions are as designated by the U.S. Bureau of the Census). Isolates from pediatric patients were virtually all susceptible to fluconazole, whereas the highest frequency of resistance was observed in isolates from patients 16 to 64 years of age.

Antifungal Agents - pharmacology

Fluconazole - pharmacology

Age Factors

United States

Humans

Middle Aged

Child, Preschool

Infant

Candidiasis - microbiology

Fungemia - microbiology

Candidiasis - drug therapy

Fungemia - drug therapy

Candida glabrata - isolation & purification

Adolescent

Aged, 80 and over

Adult

Aged

In Vitro Techniques

Child

Drug Resistance, Fungal

Candida glabrata - drug effects

Details

Title: Subtitle: Variation in susceptibility of bloodstream isolates of Candida glabrata to fluconazole according to patient age and geographic location
Creators: M A Pfaller - Department of Pathology, Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA. michael-pfaller@uiowa.edu
S A Messer
L Boyken
S Tendolkar
R J Hollis
D J Diekema
Resource Type: Journal article
Publication Details: Journal of clinical microbiology, Vol.41(5), pp.2176-2179
DOI: 10.1128/JCM.41.5.2176-2179.2003
PMID: 12734273
PMCID: PMC154732
NLM abbreviation: J Clin Microbiol
ISSN: 0095-1137
eISSN: 1098-660X
Publisher: United States
Language: English
Date published: 05/2003
Academic Unit: Infectious Diseases; Epidemiology; Pathology; Internal Medicine
Record Identifier: 9983986363902771

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