Variations in the Prevalence of Strains Expressing an Extended-Spectrum β-Lactamase Phenotype and Characterization of Isolates from Europe, the Americas, and the Western Pacific Region

P. L Winokur; R Canton; J.-M Casellas; N Legakis

doi:10.1086/320182

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Variations in the Prevalence of Strains Expressing an Extended-Spectrum β-Lactamase Phenotype and Characterization of Isolates from Europe, the Americas, and the Western Pacific Region

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Variations in the Prevalence of Strains Expressing an Extended-Spectrum β-Lactamase Phenotype and Characterization of Isolates from Europe, the Americas, and the Western Pacific Region

P. L Winokur, R Canton, J.-M Casellas and N Legakis

Clinical infectious diseases, Vol.32(Supplement-2), pp.S94-S103

05/15/2001

DOI: 10.1086/320182

PMID: 11320450

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Abstract

To evaluate the prevalence of extended-spectrum β-lactamase (ESBL)-producing strains among species of Enterobacteriaceae, a microdilution susceptibility test was performed with strains of Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, and Salmonella species that were isolated as part of the SENTRY project. The highest percentage of ESBL phenotype (defined as a minimum inhibitory concentration [MIC] ⩾2 µg/mL for ceftazidime, ceftriaxone, or aztreonam) was detected among K. pneumoniae strains from Latin America (45%), followed by those from the Western Pacific region (25%), Europe (23%), the United States (8%), and Canada (5%). P. mirabilis and E. coli strains for which MICs of extended-spectrum cephalosporins or monobactams were elevated also were more prominent in Latin America. Testing with ceftazidime revealed more isolates with elevated MICs than did testing with ceftriaxone or aztreonam. ESBL strains showed high levels of co-resistance to aminoglycosides, tetracycline, trimethoprim-sulfamethoxazole, and ciprofloxacin. Imipenem remains highly effective against ESBL strains. Organisms expressing an ESBL are widely distributed worldwide, although prevalence rates are significantly higher in certain geographic regions.

Details

Title: Subtitle: Variations in the Prevalence of Strains Expressing an Extended-Spectrum β-Lactamase Phenotype and Characterization of Isolates from Europe, the Americas, and the Western Pacific Region
Creators: P. L Winokur - University of Iowa College of Medicine, Iowa City, Iowa
R Canton - Hospital Ramon y Cajal, Madrid
J.-M Casellas - Centro de Estudios en Antimicrobianos, Victoria Punta Chica, Primeira Junta 2951, Argentina
N Legakis - National University of Athens Medical School, Athens
Resource Type: Journal article
Publication Details: Clinical infectious diseases, Vol.32(Supplement-2), pp.S94-S103
DOI: 10.1086/320182
PMID: 11320450
NLM abbreviation: Clin Infect Dis
ISSN: 1058-4838
eISSN: 1537-6591
Publisher: The University of Chicago Press
Language: English
Date published: 05/15/2001
Academic Unit: Infectious Diseases; Medicine Administration; Internal Medicine
Record Identifier: 9984094733202771

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