Varicella-Zoster Virus Glycoprotein gE: Endocytosis and Trafficking of the Fc Receptor

Julie K Olson; Richard A Santos; Charles Grose

doi:10.1086/514255

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Varicella-Zoster Virus Glycoprotein gE: Endocytosis and Trafficking of the Fc Receptor

Journal article

Open access

Peer reviewed

Varicella-Zoster Virus Glycoprotein gE: Endocytosis and Trafficking of the Fc Receptor

Julie K Olson, Richard A Santos and Charles Grose

The Journal of infectious diseases, Vol.178(Supplement-1), pp.S2-S6

11/1998

DOI: 10.1086/514255

PMID: 9852964

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Abstract

Varicella-zoster virus (VZV) encodes a functional cell membrane Fc receptor called glycoprotein gE. VZV gE resembles other mammalian cell membrane receptors, such as the mammalian Fc receptor. In further analyses by transient transfection, the cellular trafficking of VZV gE was compared to other cell surface receptors. VZV gE was shown to undergo endocytosis from the cell membrane when visualized by laser scanning confocal microscopy. The endocytosis and trafficking pathway of VZV gE followed closely the pathway defined for the human transferrin receptor. Receptor-mediated endocytosis of VZV gE was dependent on a YAGL motif in its cytoplasmic tail. In addition, VZV gE underwent receptor-mediated endocytosis when it bound the Fc portion of immunoglobulin. Thus, this detailed study of VZV gE cellular trafficking has revealed potential roles for gE during viral infection.

Details

Title: Subtitle: Varicella-Zoster Virus Glycoprotein gE: Endocytosis and Trafficking of the Fc Receptor
Creators: Julie K Olson - Departments of Microbiology and Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa
Richard A Santos - Departments of Microbiology and Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa
Charles Grose - Departments of Microbiology and Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.178(Supplement-1), pp.S2-S6
DOI: 10.1086/514255
PMID: 9852964
NLM abbreviation: J Infect Dis
ISSN: 0022-1899
eISSN: 1537-6613
Publisher: University Chicago Press
Language: English
Date published: 11/1998
Academic Unit: Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
Record Identifier: 9984093605102771

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