Journal article
Various viral compartments in HIV-1-infected mothers contribute to in utero transmission of HIV-1
AIDS research and human retroviruses, Vol.27(4), pp.421-427
04/01/2011
DOI: 10.1089/aid.2010.0160
PMID: 21034247
Abstract
Perinatal HIV transmission occurs in utero or intrapartum. The mechanisms and timing of transmission are not clearly understood. To compare the genetic sequences of the V3 envelope region of infant's plasma HIV to that of the mother's plasma, peripheral blood mononuclear cells (PBMC) and vaginal secretions, and correlate with timing of transmission. All 3 infants had a positive HIV PCR in the first days of life, thus classified as in utero infections. In the first mother-infant pair, two different variants were present in the infant, one correlating with maternal PBMC virus and highly homologous to virus from vaginal secretions and the other identical to sequences in maternal plasma. In the second pair, the infant plasma virus was similar to that of maternal PBMC. In the third pair, the cord blood and infant plasma virus were highly similar to maternal vaginal virus. The presence of more than one HIV variant from the maternal blood and from the vaginal compartment in the cord blood of infants presumably infected in utero could point to more than one episode of transmission or, alternatively, to transmission of PBMC virus.
Details
- Title: Subtitle
- Various viral compartments in HIV-1-infected mothers contribute to in utero transmission of HIV-1
- Creators
- Athena P Kourtis - National Center for Chronic Disease Prevention and Health PromotionAngela Martin Amedee - Louisiana State University Health Sciences Center New OrleansMarc Bulterys - National Center for HIV/AIDS Viral Hepatitis STD and TB PreventionSusan Danner - National Center for HIV/AIDS Viral Hepatitis STD and TB PreventionRussell Van Dyke - Tulane UniversityMary Jo O'Sullivan - University of MiamiRobert Maupin - Louisiana State University Health Sciences Center New OrleansDenise J Jamieson - National Center for Chronic Disease Prevention and Health Promotion
- Resource Type
- Journal article
- Publication Details
- AIDS research and human retroviruses, Vol.27(4), pp.421-427
- DOI
- 10.1089/aid.2010.0160
- PMID
- 21034247
- ISSN
- 0889-2229
- eISSN
- 1931-8405
- Grant note
- 417719 / PHS HHS 517715 / PHS HHS U64/217724 / PHS HHS 617734 / PHS HHS 417735 / PHS HHS
- Language
- English
- Date published
- 04/01/2011
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446535502771
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