Journal article
Varus and valgus alignment and incident and progressive knee osteoarthritis
Annals of the rheumatic diseases, Vol.69(11), pp.1940-1945
11/2010
DOI: 10.1136/ard.2010.129742
PMCID: PMC2994600
PMID: 20511608
Abstract
Varus and valgus alignment increase medial and lateral tibiofemoral load. Alignment was associated with tibiofemoral osteoarthritis progression in previous studies; an effect on incident osteoarthritis risk is less certain. This study tested whether alignment influences the risk of incident and progressive radiographic tibiofemoral osteoarthritis.
In an observational, longitudinal study of the Multicenter Osteoarthritis Study cohort, full-limb x-rays to measure alignment were acquired at baseline and knee x-rays were acquired at baseline and knee x-rays at baseline and 30 months. Varus alignment was defined as ≤178° and valgus ≥182°. Using logistic regression and generalised estimating equations, the associations of baseline alignment and incident osteoarthritis at 30 months (in knees without baseline osteoarthritis) and alignment and osteoarthritis progression (in knees with osteoarthritis) were examined, adjusting. For age, gender, body mass index, injury, laxity and strength, with neutral knees as referent.
2958 knees (1752 participants) were without osteoarthritis at baseline. Varus (adjusted OR 1.49, 95% CI 1.06 to 2.10) but not valgus alignment was associated with incident osteoarthritis. 1307 knees (950 participants) had osteoarthritis at baseline. Varus alignment was associated with a greater risk of medial osteoarthritis progression (adjusted OR 3.59, 95% CI 2.62 to 4.92) and a reduced risk of lateral progression, and valgus with a greater risk of lateral progression (adjusted OR 4.85, 95% CI 3.17 to 7.42) and a reduced risk of medial progression.
Varus but not valgus alignment increased the risk of incident tibiofemoral osteoarthritis. In knees with osteoarthritis, varus and valgus alignment each increased the risk of progression in the biomechanically stressed compartment.
Details
- Title: Subtitle
- Varus and valgus alignment and incident and progressive knee osteoarthritis
- Creators
- Leena Sharma - Northwestern University, Chicago, IL 60611, USA. l-sharma@northwestern.eduJing SongDorothy DunlopDavid FelsonCora E LewisNeil SegalJames TornerT Derek V CookeJean HietpasJohn LynchMichael Nevitt
- Resource Type
- Journal article
- Publication Details
- Annals of the rheumatic diseases, Vol.69(11), pp.1940-1945
- DOI
- 10.1136/ard.2010.129742
- PMID
- 20511608
- PMCID
- PMC2994600
- NLM abbreviation
- Ann Rheum Dis
- ISSN
- 0003-4967
- eISSN
- 1468-2060
- Publisher
- England
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS R01 HD043500 / NICHD NIH HHS U01 AG019069 / NIA NIH HHS AG19069 / NIA NIH HHS R01 AR048748 / NIAMS NIH HHS AG18947 / NIA NIH HHS U01 AG18820 / NIA NIH HHS AG18832 / NIA NIH HHS R01 HD43500 / NICHD NIH HHS U01 AG018820 / NIA NIH HHS
- Language
- English
- Date published
- 11/2010
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995100602771
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