Vasa vasorum in atherosclerotic coronary arteries: responses to vasoactive stimuli and regression of atherosclerosis

J Koudy Williams; Mark L Armstrong; Donald D Heistad

doi:10.1161/01.res.62.3.515

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Vasa vasorum in atherosclerotic coronary arteries: responses to vasoactive stimuli and regression of atherosclerosis

Journal article

Open access

Peer reviewed

Vasa vasorum in atherosclerotic coronary arteries: responses to vasoactive stimuli and regression of atherosclerosis

J Koudy Williams, Mark L Armstrong and Donald D Heistad

Circulation research, Vol.62(3), p.515

03/1988

DOI: 10.1161/01.res.62.3.515

PMID: 3342475

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Abstract

The goals of this study were to determine whether vasa vasorum in atherosclerotic coronary arteries respond to vasoactive stimuli and to examine effects of regression of atherosclerosis on blood flow through vasa vasorum in coronary arteries. We studied three groups of monkeys: normal, atherosclerotic, and regression. Blood flow to vasa vasorum was measured with microspheres. Blood flow to intima-media (ml/min x 100 g) was 5 +/- 1 (mean +/- SEM) in normal and 47 +/- 7 in atherosclerotic monkeys (p less than 0.05). Infusion of phenylephrine or serotonin did not alter flow through vasa in normal monkeys. In atherosclerotic monkeys, phenylephrine decreased flow through vasa vasorum in intima-media of coronary arteries to 24 +/- 4 (p less than 0.05), and serotonin decreased flow to 27 +/- 5 (p less than 0.05). In regression monkeys, blood flow to intima-media was sixfold less (7 +/- 2 ml/min x 100 g) than in atherosclerotic monkeys (p less than 0.05). During infusion of adenosine, blood flow to vasa was fourfold greater in atherosclerotic monkeys than after regression of atherosclerosis. This finding suggests that loss of vessels, not constriction of existing vessels, accounts for the decrease in flow through vasa in intima-media after regression of atherosclerosis. We conclude that vasa vasorum in atherosclerotic coronary arteries respond to vasoconstrictor stimuli and that there is loss of vasa vasorum and a large decrease in blood flow through vasa to intima-media of coronary arteries after regression of atherosclerosis.

Coronary Circulation

Coronary Vessels - pathology

Animals

Coronary Artery Disease - physiopathology

Vasomotor System - physiopathology

Coronary Vessels - physiopathology

Coronary Artery Disease - pathology

Macaca fascicularis

Male

Vasa Vasorum - pathology

Regional Blood Flow

Vasa Vasorum - physiopathology

Details

Title: Subtitle: Vasa vasorum in atherosclerotic coronary arteries: responses to vasoactive stimuli and regression of atherosclerosis
Creators: J Koudy Williams - Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, Iowa
Mark L Armstrong
Donald D Heistad
Resource Type: Journal article
Publication Details: Circulation research, Vol.62(3), p.515
DOI: 10.1161/01.res.62.3.515
PMID: 3342475
NLM abbreviation: Circ Res
ISSN: 0009-7330
eISSN: 1524-4571
Publisher: United States
Grant note: HL 14230 / NHLBI NIH HHS HL 14388 / NHLBI NIH HHS HL 07371 / NHLBI NIH HHS
Language: English
Date published: 03/1988
Academic Unit: Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040247402771

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