Journal article
Vascular Contributions to Migraine: Time to Revisit?
Frontiers in cellular neuroscience, Vol.12, pp.233-233
08/03/2018
DOI: 10.3389/fncel.2018.00233
PMCID: PMC6088188
PMID: 30127722
Abstract
Migraine is one of the most prevalent and disabling neurovascular disorders worldwide. However, despite the increase in awareness and research, the understanding of migraine pathophysiology and treatment options remain limited. For centuries, migraine was considered to be a vascular disorder. In fact, the throbbing, pulsating quality of the headache is thought to be caused by mechanical changes in vessels. Moreover, the most successful migraine treatments act on the vasculature and induction of migraine can be accomplished with vasoactive agents. However, over the past 20 years, the emphasis has shifted to the neural imbalances associated with migraine, and vascular changes have generally been viewed as an epiphenomenon that is neither sufficient nor necessary to induce migraine. With the clinical success of peripherally-acting antibodies that target calcitonin gene-related peptide (CGRP) and its receptor for preventing migraine, this neurocentric view warrants a critical re-evaluation. This review will highlight the likely importance of the vasculature in migraine.
Details
- Title: Subtitle
- Vascular Contributions to Migraine: Time to Revisit?
- Creators
- Bianca N Mason - Department of Molecular Physiology and Biophysics, University of IowaAndrew F Russo - Department of Molecular Physiology and Biophysics, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Frontiers in cellular neuroscience, Vol.12, pp.233-233
- DOI
- 10.3389/fncel.2018.00233
- PMID
- 30127722
- PMCID
- PMC6088188
- NLM abbreviation
- Front Cell Neurosci
- ISSN
- 1662-5102
- eISSN
- 1662-5102
- Publisher
- Frontiers Media S.A
- Grant note
- NS075599, F31NS098825 / National Institutes of Health W81XWH-16-1-0071, W81XWH-16-1-0211 / U.S. Department of Defense 1I01RX002101 / U.S. Department of Veterans Affairs
- Language
- English
- Date published
- 08/03/2018
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070684802771
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