Journal article
Vascular Deformation Mapping for CT Surveillance of Thoracic Aortic Aneurysm Growth
Radiology, Vol.302(1), pp.218-225
10/19/2021
DOI: 10.1148/radiol.2021210658
PMCID: PMC8717815
PMID: 34665030
Abstract
Background
Aortic diameter measurements in patients with a thoracic aortic aneurysm (TAA) show wide variation. There is no technique to quantify aortic growth in a three-dimensional (3D) manner.
Purpose
To validate a CT-based technique for quantification of 3D growth based on deformable registration in patients with TAA.
Materials and Methods
Patients with ascending and descending TAA with two or more CT angiography studies between 2006 and 2020 were retrospectively identified. The 3D aortic growth was quantified using vascular deformation mapping (VDM), a technique that uses deformable registration to warp a mesh constructed from baseline aortic anatomy. Growth assessments between VDM and clinical CT diameter measurements were compared. Aortic growth was quantified as the ratio of change in surface area at each mesh element (area ratio). Manual segmentations were performed by independent raters to assess interrater reproducibility. Registration error was assessed using manually placed landmarks. Agreement between VDM and clinical diameter measurements was assessed using Pearson correlation and Cohen κ coefficients.
Results
A total of 38 patients (68 surveillance intervals) were evaluated (mean age, 69 years ± 9 [standard deviation]; 21 women), with TAA involving the ascending aorta (n = 26), descending aorta (n = 10), or both (n = 2). VDM was technically successful in 35 of 38 (92%) patients and 58 of 68 intervals (85%). Median registration error was 0.77 mm (interquartile range, 0.54–1.10 mm). Interrater agreement was high for aortic segmentation (Dice similarity coefficient = 0.97 ± 0.02) and VDM-derived area ratio (bias = 0.0, limits of agreement: −0.03 to 0.03). There was strong agreement (r = 0.85, P < .001) between peak area ratio values and diameter change. VDM detected growth in 14 of 58 (24%) intervals. VDM revealed growth outside the maximally dilated segment in six of 14 (36%) growth intervals, none of which were detected with diameter measurements.
Conclusion
Vascular deformation mapping provided reliable and comprehensive quantitative assessment of three-dimensional aortic growth and growth patterns in patients with thoracic aortic aneurysms undergoing CT surveillance.
Details
- Title: Subtitle
- Vascular Deformation Mapping for CT Surveillance of Thoracic Aortic Aneurysm Growth
- Creators
- Nicholas S BurrisZhangxing BianJeffrey DominicJianyang ZhongIgnas B HoubenTheodorus M. J van BakelHimanshu J PatelBrian D RossGary E ChristensenCharles R Hatt
- Resource Type
- Journal article
- Publication Details
- Radiology, Vol.302(1), pp.218-225
- DOI
- 10.1148/radiol.2021210658
- PMID
- 34665030
- PMCID
- PMC8717815
- NLM abbreviation
- Radiology
- ISSN
- 0033-8419
- eISSN
- 1527-1315
- Grant note
- DOI: 10.13039/100006098, name: Radiological Society of North America Research Scholar Grant, award: RSCH1801; DOI: 10.13039/100000002, name: National Institutes of Health, award: SBIRR44 HL145953; name: David Hamilton Fund; name: Phil Jenkins Breakthrough Fund; name: Joe D. Morris Collegiate Professorship in Cardiac Surgery; DOI: 10.13039/100000002, name: National Institutes of Health, award: R35 CA197701; DOI: 10.13039/100000002, name: National Institutes of Health, award: R44 HL145953
- Language
- English
- Date published
- 10/19/2021
- Academic Unit
- Electrical and Computer Engineering; Iowa Technology Institute; Radiation Oncology; Radiation Research Laboratory; The Iowa Institute for Biomedical Imaging; Holden Comprehensive Cancer Center
- Record Identifier
- 9984198000702771
Metrics
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