Journal article
Vascular Endothelial Dysfunction in Patients with Newly Diagnosed Type 2 Diabetes and Effects of 2-year and 5-year Multifactorial Intervention
Echocardiography (Mount Kisco, N.Y.), Vol.28(10), pp.1133-1140
11/01/2011
DOI: 10.1111/j.1540-8175.2011.01514.x
PMID: 21967242
Abstract
Objectives: Investigate short- and long-term effect of multifactorial intervention on endothelial dysfunction in patients with newly diagnosed type 2 diabetes. Background: Whether multifactorial intervention reduces cardiovascular risk in type 2 diabetes is largely controversial, partially because of lack of reliable method for endothelial dysfunction detection. Using high-resolution ultrasonographical flow-mediated vasodilatation (FMD), we completed a 5-year randomized prospective intervention trial in patients with newly diagnosed type 2 diabetes. We have studied the effect of multifactorial intervention therapy on their endothelial dysfunction. Methods: One hundred eight patients with newly diagnosed type 2 diabetes, and 83 healthy subjects received measurement of brachial artery FMD and endothelium-independent dilatation (EID). Diabetic patients were assigned into four groups, treated with: (A) hypoglycemic and antihypertensive agents, (B) hypoglycemic, antihypertensive and lipid-lowering agents, (C) hypoglycemic, antihypertensive and lipid-lowering agents, and vitamin E, and (D) hypoglycemic, antihypertensive and lipid-lowering agents, and compound salvia tablets. Both FMD and EID were remeasured after 24- and 60-month treatment. Results: FMD in diabetic patients was significantly lower than those in healthy subjects. After 24-month treatment, there was no FMD change. However, FMD improved significantly after 60-month treatment. The differences between 24- and 60-month are also significant. EID did not change significantly after both 24- and 60-month treatments. Conclusions: (1) FMD-detectable endothelial dysfunction exists in newly diagnosed type 2 diabetic patients. (2) Reverse of endothelial function occurs only after long-term (60-month) multifactorial intervention. (3) FMD could potentially help early identification, stratification, and treatment of endothelial dysfunction in type 2 diabetic patients. (Echocardiography 2011;28:1133-1140)
Details
- Title: Subtitle
- Vascular Endothelial Dysfunction in Patients with Newly Diagnosed Type 2 Diabetes and Effects of 2-year and 5-year Multifactorial Intervention
- Creators
- Jing Tian - Sun Yat-sen Memorial HospitalYanling Wen - Sun Yat-sen Memorial HospitalLi Yan - Sun Yat-sen Memorial HospitalHua Cheng - Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510120, Guangdong, Peoples R ChinaHaiyun Yang - Sun Yat-sen Memorial HospitalJingfeng Wang - Sun Yat-sen Memorial HospitalHani Kozman - SUNY Upstate Medical UniversityDaniel Villarreal - SUNY Upstate Medical UniversityKan Liu - SUNY Upstate Medical University
- Resource Type
- Journal article
- Publication Details
- Echocardiography (Mount Kisco, N.Y.), Vol.28(10), pp.1133-1140
- Publisher
- Wiley
- DOI
- 10.1111/j.1540-8175.2011.01514.x
- PMID
- 21967242
- ISSN
- 0742-2822
- eISSN
- 1540-8175
- Number of pages
- 8
- Grant note
- 2001BA702B01/2004BA702B/2006BAI02B08 / Chinese National Key Science & Technology Program
- Language
- English
- Date published
- 11/01/2011
- Academic Unit
- Radiology; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984318705902771
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