Journal article
Vascular Function in Women with Heart Failure with Preserved Ejection Fraction: A Mismatch Beyond Diastole
Journal of applied physiology (1985), Vol.139(3), pp.747-758
09/2025
DOI: 10.1152/japplphysiol.00467.2025
PMCID: PMC12419534
PMID: 40839391
Abstract
Heart failure with preserved ejection fraction (HFpEF) is a complex multi-organ clinical syndrome representing ~50% of all heart failure related cases nationwide. HFpEF is more prevalent in women yet both men and women with HFpEF present with distinct clinical phenotypes and prognosis that may be attributable, in part, to sex differences in anatomical, physiological, and/or hormonal characteristics. Of particular interest is the role of sex hormones, namely estrogen, as a contributing factor to sex differences in vascular health in patients with HFpEF. This mini review provides a summary of recent evidence regarding sex differences in coronary microvascular function, peripheral vascular function, and central arterial stiffness in patients with HFpEF. Focus will also be given to potential mechanisms by which age-related loss of estrogen may alter these aspects of physiology in women with HFpEF and provide potential future directions related to implications for women‘s health in adults with HFpEF.
Details
- Title: Subtitle
- Vascular Function in Women with Heart Failure with Preserved Ejection Fraction: A Mismatch Beyond Diastole
- Creators
- Nicholas A. Carlini - University of UtahD. Walter Wray - University of UtahKerrie L. Moreau - University of Colorado Anschutz Medical CampusKanokwan Bunsawat - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.139(3), pp.747-758
- DOI
- 10.1152/japplphysiol.00467.2025
- PMID
- 40839391
- PMCID
- PMC12419534
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Publisher
- AMER PHYSIOLOGICAL SOC
- Grant note
- Department of Veterans Affairs Advanced Fellowship in GeriatricsNational Institutes of Health: R01 HL162856, R01 HL170007, R01 AG089069, R01 AG049762, R56 AG072094, R01 AG027678 National Institutes of Aging: U54AG062319 Eastern Colorado VA GRECCU.S. Department of Veterans Affairs: I01 CX002152, I01 CX002762, IK2RX003670
This work was funded, in part, by Department of Veterans Affairs Advanced Fellowship in Geriatrics (to N.A.C.), the National Institutes of Health [R01 HL162856 (to D.W.W.); R01 HL170007 (to D.W.W.); R01 AG089069 (to K.L.M.); R01 AG049762 (to K.L.M.); R56 AG072094 (to K.L.M.); and R01 AG027678 (to K.L.M.)], the National Institutes of Aging [U54AG062319 (to K.L.M.)], Eastern Colorado VA GRECC (to K.L.M.), and the U.S. Department of Veterans Affairs [I01 CX002152 (to D.W.W.); I01 CX002762 (to K.L.M.); and IK2RX003670 (to K.B.)].
- Language
- English
- Electronic publication date
- 08/21/2025
- Date published
- 09/2025
- Academic Unit
- Health, Sport, and Human Physiology
- Record Identifier
- 9984958345202771
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