Journal article
Vascular Smooth Muscle Cells in Cerebral Aneurysm Pathogenesis
Translational stroke research, Vol.5(3), pp.338-346
06/2014
DOI: 10.1007/s12975-013-0290-1
PMID: 24323713
Abstract
Vascular smooth muscle cells (SMC) maintain significant plasticity. Following environmental stimulation, SMC can alter their phenotype from one primarily concerned with contraction to a pro-inflammatory and matrix remodeling phenotype. This is a critical process behind peripheral vascular disease and atherosclerosis, a key element of cerebral aneurysm pathology. Evolving evidence demonstrates that SMCs and phenotypic modulation play a significant role in cerebral aneurysm formation and rupture. Pharmacological alteration of smooth muscle cell function and phenotypic modulation could provide a promising medical therapy to inhibit cerebral aneurysm progression. This study reviews vascular SMC function and its contribution to cerebral aneurysm pathophysiology.
Details
- Title: Subtitle
- Vascular Smooth Muscle Cells in Cerebral Aneurysm Pathogenesis
- Creators
- Robert Starke - Department of Neurological Surgery University of Virginia Charlottesville VA USANohra Chalouhi - Department of Neurosurgery Thomas Jefferson University Philadelphia PA USADale Ding - Department of Neurological Surgery University of Virginia Charlottesville VA USADaniel Raper - Department of Neurological Surgery University of Virginia Charlottesville VA USAM Mckisic - Department of Neurological Surgery University of Virginia Charlottesville VA USAGary Owens - Department of Molecular Physiology and Biophysics Robert M. Berne Cardiovascular Research Center Charlottesville VA USADavid Hasan - Department of Neurological Surgery University of Iowa Iowa City IA USARicky Medel - Department of Neurological Surgery Tulane University 131 S. Robertson St., Suite 1300 New Orleans LA 70112 USAAaron Dumont - Department of Neurological Surgery Tulane University 131 S. Robertson St., Suite 1300 New Orleans LA 70112 USA
- Resource Type
- Journal article
- Publication Details
- Translational stroke research, Vol.5(3), pp.338-346
- Publisher
- Springer US; Boston
- DOI
- 10.1007/s12975-013-0290-1
- PMID
- 24323713
- ISSN
- 1868-4483
- eISSN
- 1868-601X
- Language
- English
- Date published
- 06/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurosurgery; Otolaryngology
- Record Identifier
- 9984040231502771
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