Journal article
Vascular actions of histamine H1 - and H2-receptor agonists in dogs and cats
European journal of pharmacology, Vol.45(1), pp.73-77
09/1977
DOI: 10.1016/0014-2999(77)90060-7
PMID: 891621
Abstract
Systemic and pulmonary vascular responses to infusions of histamine, 2-methylhistamine (2-MeH), and 4-methylhistamine (4-MeH) were determined. In dogs, H1-receptor stimulation with 2-MeH induced pulmonary vasoconstriction, and a decrease in cardiac output. H2-receptor stimulation with 4-MeH induced pulmonary and systemic vasodilation, tachycardia, and an increase in cardiac output. In cats, 2-MeH caused slight pulmonary vasoconstriction and 4-MeH caused vasodilation. Both H1- and H2-receptors mediated the systemic vasodilation, tachycardia, and increase in cardiac output observed in cats.
Details
- Title: Subtitle
- Vascular actions of histamine H1 - and H2-receptor agonists in dogs and cats
- Creators
- Alan TuckerEric A HoffmanJohn T Reeves
- Resource Type
- Journal article
- Publication Details
- European journal of pharmacology, Vol.45(1), pp.73-77
- DOI
- 10.1016/0014-2999(77)90060-7
- PMID
- 891621
- ISSN
- 0014-2999
- eISSN
- 1879-0712
- Language
- English
- Date published
- 09/1977
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051714102771
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