Vascular and Neural Dysfunctions in Obese Zucker Rats: Effect of AVE7688

Eric P Davidson; Lawrence J Coppey; Travis L Kleinschmidt; Christine L Oltman; Mark A Yorek

doi:10.1155/2009/912327

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Vascular and Neural Dysfunctions in Obese Zucker Rats: Effect of AVE7688

Journal article

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Vascular and Neural Dysfunctions in Obese Zucker Rats: Effect of AVE7688

Eric P Davidson, Lawrence J Coppey, Travis L Kleinschmidt, Christine L Oltman and Mark A Yorek

Experimental diabetes research, Vol.2009, 912327

2009

DOI: 10.1155/2009/912327

PMCID: PMC2695958

PMID: 19536347

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https://doi.org/10.1155/2009/912327View

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Abstract

The purpose of this study was to determine whether AVE7688 a drug that inhibits both angiotensin converting enzyme and neutral endopeptidase activity protects vascular and nerve functions in an animal model of metabolic syndrome. Obese Zucker rats at 20 weeks of age were treated for 12 weeks with AVE7688. Vasodilation in epineurial arterioles was measured by videomicroscopy and nerve conduction velocity was measured following electrical stimulation. Treatment with AVE7688 improved vascular relaxation in response to acetylcholine and motor and sensory nerve conduction velocity. In obese Zucker rats superoxide levels and nitrotyrosine staining were elevated in the aorta and treatment corrected both conditions. Obese Zucker rats were hypoalgesic in response to a thermal stimulus and demonstrated signs of impaired tactile response and both conditions were significantly improved with treatment. Even though obese Zucker rats are normoglycemic vascular and neural dysfunctions develop with age and can be improved by treatment with AVE7688.

Details

Title: Subtitle: Vascular and Neural Dysfunctions in Obese Zucker Rats: Effect of AVE7688
Creators: Eric P Davidson - Department of Veterans Affairs Iowa City Health Care System, University of Iowa, Iowa City, IA 52246, USA, Department of Internal Medicine, University of Iowa, Iowa City, IA 52246, USA
Lawrence J Coppey - Department of Veterans Affairs Iowa City Health Care System, University of Iowa, Iowa City, IA 52246, USA, Department of Internal Medicine, University of Iowa, Iowa City, IA 52246, USA
Travis L Kleinschmidt - Department of Veterans Affairs Iowa City Health Care System, University of Iowa, Iowa City, IA 52246, USA, Department of Internal Medicine, University of Iowa, Iowa City, IA 52246, USA
Christine L Oltman - Department of Veterans Affairs Iowa City Health Care System, University of Iowa, Iowa City, IA 52246, USA, Department of Internal Medicine, University of Iowa, Iowa City, IA 52246, USA
Mark A Yorek - Department of Veterans Affairs Iowa City Health Care System, University of Iowa, Iowa City, IA 52246, USA, Department of Internal Medicine, University of Iowa, Iowa City, IA 52246, USA
Resource Type: Journal article
Publication Details: Experimental diabetes research, Vol.2009, 912327
DOI: 10.1155/2009/912327
PMID: 19536347
PMCID: PMC2695958
NLM abbreviation: Exp Diabetes Res
ISSN: 1687-5214
eISSN: 1687-5303
Grant note: DOI: 10.13039/100000738, name: U.S. Department of Veterans Affairs, award: DK073990
Language: English
Date published: 2009
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984094654302771

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