Journal article
Vascular and cognitive functions associated with cardiovascular disease in the elderly
Journal of clinical and experimental neuropsychology, Vol.31(1), pp.96-110
01/01/2009
DOI: 10.1080/13803390802014594
PMCID: PMC2739675
PMID: 18608677
Abstract
This study examines the relationship between systemic vascular function, neurocognitive performance, and structural brain abnormalities on magnetic resonance imaging (MRI) among geriatric outpatients with treated, stable cardiovascular disease and no history of neurological illness (n = 88, ages 56-85 years). Vascular function was assessed by cardiac ejection fraction and output, sequential systolic and diastolic blood pressures, flow mediated brachial artery reactivity (BAR), and carotid intima media thickness (IMT). White matter hyperintensities (WMH) on MRI were quantified and examined relative to cognitive and vascular function. Principal component analysis revealed two primary vascular components: one associated with cardiac function, the other with atherosclerotic burden/endothelial dysfunction. Both factors were significantly associated with cognitive function and WMH volume. Reduced systolic variability and increased IMT were most strongly related to reduced attention, executive function, and information-processing speed. These findings suggest the possibility that systemic vascular indices may provide proxy measures of cerebrovascular dysfunction and reinforce the importance of achieving greater understanding of interaction between systemic vascular disease and brain dysfunction among elderly people with cardiovascular disease.
Details
- Title: Subtitle
- Vascular and cognitive functions associated with cardiovascular disease in the elderly
- Creators
- Ronald A Cohen - Department of Psychiatry and Human Behavior , Warren Alpert Medical School, Brown UniversityAthena Poppas - Department of Cardiology, Rhode Island Hospital , Warren Alpert Medical School, Brown UniversityDaniel E Forman - Division of Cardiology, Brigham and Women's Hospital and Geriatric Research, Education, and Clinical Care, VA Boston Health Care System, Harvard Medical SchoolKarin F Hoth - Department of Medicine, National Jewish Medical and Research Center, and Department of Psychiatry , University of ColoradoAndreana P Haley - Department of Psychology , The University of Texas at AustinJohn Gunstad - Department of Psychology , Kent State UniversityAngela L Jefferson - Department of Neurology , Boston University School of MedicineDavid F Tate - Department of Psychiatry and Human Behavior , Warren Alpert Medical School, Brown UniversityRobert H Paul - Department of Psychology, Behavioral Neuroscience , University of MissouriLawrence H Sweet - Department of Psychiatry and Human Behavior , Warren Alpert Medical School, Brown UniversityMokato Ono - Department of Psychiatry and Human Behavior , Warren Alpert Medical School, Brown UniversityBeth A Jerskey - Department of Psychiatry and Human Behavior , Warren Alpert Medical School, Brown UniversityMarie Gerhard-Herman - Division of Cardiology, Brigham and Women's Hospital and Geriatric Research, Education, and Clinical Care, VA Boston Health Care System, Harvard Medical School
- Resource Type
- Journal article
- Publication Details
- Journal of clinical and experimental neuropsychology, Vol.31(1), pp.96-110
- DOI
- 10.1080/13803390802014594
- PMID
- 18608677
- PMCID
- PMC2739675
- NLM abbreviation
- J Clin Exp Neuropsychol
- ISSN
- 1380-3395
- eISSN
- 1744-411X
- Publisher
- Informa UK Limited
- Language
- English
- Date published
- 01/01/2009
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984066385502771
Metrics
24 Record Views