Vascular calcification by conventional X-ray and mortality in a cohort of predominantly African descent hemodialysis patients

Maria Tereza S Martins; Cácia M Matos; Marcelo B Lopes; Angiolina C Kraychete; Gildete B Lopes; Márcia Tereza S Martins; João Luiz Fernandes; Maurício K Amoedo; Carolina L Neves; Antonio A Lopes

doi:10.1177/0391398820962805

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Vascular calcification by conventional X-ray and mortality in a cohort of predominantly African descent hemodialysis patients

Journal article

Peer reviewed

Vascular calcification by conventional X-ray and mortality in a cohort of predominantly African descent hemodialysis patients

Maria Tereza S Martins, Cácia M Matos, Marcelo B Lopes, Angiolina C Kraychete, Gildete B Lopes, Márcia Tereza S Martins, João Luiz Fernandes, Maurício K Amoedo, Carolina L Neves and Antonio A Lopes

International journal of artificial organs, Vol.44(5), pp.318-324

05/2021

DOI: 10.1177/0391398820962805

PMID: 33063583

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Abstract

There is a lack of studies describing the prevalence of vascular calcification (VC) and its association with mortality in maintenance hemodialysis (MHD) patients of African descent. We investigated if a VC score based on the number of calcified vascular beds was associated with mortality in MHD patients. We analyzed data from 211 MHD patients enrolled from January 2010 to January 2011 in the prospective cohort study, "The Prospective Study of the Prognosis of Chronic Hemodialysis Patients (PROHEMO)," developed in Salvador, BA, Brazil. VC was evaluated using radiographs of the hands, abdomen, hip, and chest; the score was calculated by the number of calcified sites as 0 (absence of calcification), 1 (one calcified site), 2 (two sites), 3 (⩾3 sites). We used Cox's regression to estimate the hazard ratio (HR) and 95% confidence interval (CI) of associations between VC and mortality with adjustments for age and comorbidities. VC was detected in 114 (54.0%) patients; 37 (17.5%) with a VC score = 1; 21 (10%) with VC score = 2 and 56 (26.5%) with VC score = 3. Compared with VC score = 0, the adjusted hazard of death was 2.67 (95% CI: 1.12, 6.33) for patients with VC score = 1; HR = 2.89 (95% CI: 0.95, 7.63) for VC score = 2; and HR = 3.27 (95% CI: 1.47, 7.28) for VC score = 3. The present study in an African descent MHD population provides support for the VC score based on conventional radiography as a prediction tool for the clinical practice. As shown, the VC score was monotonically and independently associated with mortality.

Blacks

Brazil

Radiography

Adult

Aged

Female

Humans

Male

Middle Aged

Prospective Studies

Renal Dialysis - mortality

Risk Factors

Vascular Calcification - diagnostic imaging

Vascular Calcification - mortality

X-Rays

Details

Title: Subtitle: Vascular calcification by conventional X-ray and mortality in a cohort of predominantly African descent hemodialysis patients
Creators: Maria Tereza S Martins - Universidade Federal da Bahia
Cácia M Matos - Universidade Federal da Bahia
Marcelo B Lopes - Universidade Federal da Bahia
Angiolina C Kraychete - Universidade Federal da Bahia
Gildete B Lopes - Unit of Clinical Epidemiology and Evidence Based Medicine, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, BA, Brazil
Márcia Tereza S Martins - Universidade Federal da Bahia
João Luiz Fernandes
Maurício K Amoedo - AC Camargo Hospital
Carolina L Neves - Universidade Federal da Bahia
Antonio A Lopes - Complexo Hospitalar Universitário Professor Edgard Santos
Resource Type: Journal article
Publication Details: International journal of artificial organs, Vol.44(5), pp.318-324
DOI: 10.1177/0391398820962805
PMID: 33063583
NLM abbreviation: Int J Artif Organs
ISSN: 0391-3988
eISSN: 1724-6040
Language: English
Date published: 05/2021
Academic Unit: Radiology
Record Identifier: 9984697731602771

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