Journal article
Vascular endothelial function is not related to serum uric acid in healthy adults
American journal of hypertension, Vol.25(4), pp.407-413
04/2012
DOI: 10.1038/ajh.2011.237
PMCID: PMC3309158
PMID: 22237152
Abstract
Some experimental evidence suggests that uric acid impairs endothelial function. It is controversial if high uric acid levels and impaired endothelial function are related in healthy adults. In addition, the effect of uric acid on endothelial cells (ECs) of humans is unexplored.
Data of 107 healthy adult volunteers were analyzed. The association between serum uric acid and endothelial-dependant dilation (EDD) and endothelial-independent dilation (EID) was evaluated by linear regression models. We also examined the relations between uric acid and systemic and cellular markers of inflammation and oxidative stress in all or subsets of participants.
Uric acid levels and EDD were not related in unadjusted or adjusted models. There was a significant negative correlation between uric acid and EID in the pooled sample (r = -0.34, P = 0.005). This correlation remained significant after adjusting for demographics (P = 0.04) and was attenuated after adjusting for other cardiac risk factors (P = 0.12). Higher serum uric acid levels were found to correlate significantly with C-reactive protein (CRP) (r = 0.31, P = 0.002). Serum uric acid levels were not associated with brachial artery EC nuclear factor-κB (NF-κB) p65 or NADPH oxidase p47(phox) expression or with nitrotyrosine staining, but were inversely associated with EC manganese superoxide dismutase (MnSOD) expression (r = -0.5, P = 0.01, n = 25).
Elevated serum uric acid is not associated with endothelial dysfunction among healthy adults, but is inversely related to EID and EC MnSOD, and positively related to systemic inflammation. These findings may have implications for cardiovascular risk in healthy adults.
Details
- Title: Subtitle
- Vascular endothelial function is not related to serum uric acid in healthy adults
- Creators
- Diana I Jalal - Division of Renal Diseases and Hypertension, University of Colorado Denver, USA. Diana.Jalal@ucdenver.eduKristen L JablonskiKim McFannMichel B ChoncholDouglas R Seals
- Resource Type
- Journal article
- Publication Details
- American journal of hypertension, Vol.25(4), pp.407-413
- DOI
- 10.1038/ajh.2011.237
- PMID
- 22237152
- PMCID
- PMC3309158
- ISSN
- 0895-7061
- eISSN
- 1879-1905
- Grant note
- R01 DK081473-01A1 / NIDDK NIH HHS R01 DK081473 / NIDDK NIH HHS AG006537 / NIA NIH HHS 1K23DK088833-01 / NIDDK NIH HHS R01 AG006537 / NIA NIH HHS F31 AG033994 / NIA NIH HHS UL1 RR025780 / NCRR NIH HHS R37 AG013038 / NIA NIH HHS AG033994 / NIA NIH HHS R01DK078112-01A2 / NIDDK NIH HHS K23 DK088833 / NIDDK NIH HHS AG013038 / NIA NIH HHS R01 AG013038 / NIA NIH HHS R01 DK078112 / NIDDK NIH HHS RR025780 / NCRR NIH HHS
- Language
- English
- Date published
- 04/2012
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094513102771
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