Journal article
Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults
Hypertension (Dallas, Tex. 1979), Vol.55(2), pp.363-369
02/2010
DOI: 10.1161/HYPERTENSIONAHA.109.145870
PMCID: PMC2880882
PMID: 20048194
Abstract
Endothelium-dependent dilation (EDD) is impaired with aging, but there is significant variability among healthy middle-aged and older adults. We tested the hypothesis that EDD is related to white blood cell (WBC) count in healthy men and women aged 55 to 75 years (n=48) who have a WBC count within the clinically normal range. The peak forearm blood flow response to intrabrachial artery infusion of acetylcholine was inversely related to WBC count (r=-0.38; P=0.004) and was 34% smaller in subjects with higher versus lower WBC count (more versus less than the median of 5.0x10(9) cells per liter; P=0.001). Vascular smooth muscle responsiveness to NO (peak forearm blood flow response to sodium nitroprusside) was inversely related to WBC count (r=-0.30; P=0.02) but did not fully explain the associations with EDD. Inhibition of NO with N(G)-monomethyl-L-arginine reduced EDD in subjects with lower (-56%; P=0.01) but not higher WBC count. Tetrahydrobiopterin selectively improved EDD in subjects with higher WBC count (+35%; P=0.01) by increasing NO bioavailability. EDD was related (P<0.05) to neutrophil, eosinophil, and monocyte but not lymphocyte or basophil counts. Myeloperoxidase, which is secreted by neutrophils and monocytes, consumes NO and produces molecules that oxidize tetrahydrobiopterin, was inversely related to EDD (r=-0.35; P=0.02), and was 42% higher in subjects with a higher WBC count (P=0.02). No other factors contributed to the relation between EDD and WBC count. Among healthy middle-aged and older adults, impaired EDD is related to higher neutrophil, eosinophil, and monocyte-based WBC count mediated by reduced responsiveness to NO and increased myeloperoxidase-associated reductions in tetrahydrobiopterin and NO bioavailability.
Details
- Title: Subtitle
- Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults
- Creators
- Ashley E Walker - University of Colorado BoulderSara Marian Seibert - University of Colorado BoulderAnthony J Donato - University of Colorado BoulderGary L Pierce - University of Colorado BoulderDouglas R Seals - University of Colorado Boulder
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.55(2), pp.363-369
- DOI
- 10.1161/HYPERTENSIONAHA.109.145870
- PMID
- 20048194
- PMCID
- PMC2880882
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Grant note
- AG031141 / NIA NIH HHS R01 AG006537-23 / NIA NIH HHS R01 AG031141 / NIA NIH HHS AG006537 / NIA NIH HHS R01 AG006537 / NIA NIH HHS AG031617 / NIA NIH HHS F31 AG031617 / NIA NIH HHS R37 AG013038-14 / NIA NIH HHS R01 AG031141-02 / NIA NIH HHS AG013038 / NIA NIH HHS R01 AG015897 / NIA NIH HHS F31 AG031617-02 / NIA NIH HHS R01 AG022241 / NIA NIH HHS AG022241 / NIA NIH HHS R01 AG015897-10 / NIA NIH HHS K01 AG029337-03 / NIA NIH HHS RR00051 / NCRR NIH HHS M01 RR000051 / NCRR NIH HHS R37 AG013038 / NIA NIH HHS T32 AG000279-08 / NIA NIH HHS AG000279 / NIA NIH HHS AG015897 / NIA NIH HHS K01 AG029337 / NIA NIH HHS AG029337 / NIA NIH HHS R01 AG013038 / NIA NIH HHS T32 AG000279 / NIA NIH HHS R01 AG022241-04 / NIA NIH HHS
- Language
- English
- Date published
- 02/2010
- Academic Unit
- Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984267247502771
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