Vascular function is not impaired early in the course of bipolar disorder

Dylan P Murray; Nora S Metz; William G Haynes; Jess G Fiedorowicz

doi:10.1016/j.jpsychores.2011.12.006

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Vascular function is not impaired early in the course of bipolar disorder

Journal article

Peer reviewed

Vascular function is not impaired early in the course of bipolar disorder

Dylan P Murray, Nora S Metz, William G Haynes and Jess G Fiedorowicz

Journal of psychosomatic research, Vol.72(3), pp.195-198

03/2012

DOI: 10.1016/j.jpsychores.2011.12.006

PMCID: PMC3278715

PMID: 22325698

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Abstract

Individuals with bipolar disorder face a nearly two-fold increased risk of cardiovascular mortality relative to the general population. Endothelial dysfunction precedes cardiovascular disease and serves as a quantifiable phenotype for vasculopathy. We investigated whether individuals with bipolar disorder had poorer vascular function than controls using a case–control design. The sample of 54 participants included 27 individuals with bipolar disorder and 27 age- and gender-matched controls. Participants underwent an assessment of metabolic (weight, lipids, and insulin resistance) and vascular parameters (endothelial function using flow-mediated dilation; arterial stiffness using pulse wave velocity and estimated aortic pressure). Participants had a mean age of 32years and 41% were female. No significant differences were found between groups in endothelial function or arterial stiffness. Individuals with bipolar disorder demonstrated 100% greater insulin resistance. The lack of clinically significant differences in vascular function in this young sample suggests any increased risk either occurs later in the course of illness or is largely due to behavioral risk factors, such as smoking, which was balanced between groups. Substantial insulin resistance is identifiable early in course of illness, perhaps secondary to treatment.

Endothelial dysfunction

Bipolar disorder

Cardiovascular disease

Insulin resistance

Pulse wave analysis

Cardiovascular mortality

Details

Title: Subtitle: Vascular function is not impaired early in the course of bipolar disorder
Creators: Dylan P Murray - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, United States
Nora S Metz - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, United States
William G Haynes - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, United States
Jess G Fiedorowicz - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, United States
Resource Type: Journal article
Publication Details: Journal of psychosomatic research, Vol.72(3), pp.195-198
DOI: 10.1016/j.jpsychores.2011.12.006
PMID: 22325698
PMCID: PMC3278715
NLM abbreviation: J Psychosom Res
ISSN: 0022-3999
eISSN: 1879-1360
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: 1K23MH083695-01A210; name: Institute for Clinical and Translational Science at the University of Iowa, award: 3 UL1 RR024979-03S4
Language: English
Date published: 03/2012
Academic Unit: Psychiatry; Epidemiology; Iowa Neuroscience Institute
Record Identifier: 9984065397902771

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