Journal article
Vascular protection: superoxide dismutase isoforms in the vessel wall
Arteriosclerosis, thrombosis, and vascular biology, Vol.24(8), pp.1367-1373
08/2004
DOI: 10.1161/01.ATV.0000133604.20182.cf
PMID: 15166009
Abstract
Blood vessels express 3 isoforms of superoxide dismutase (SOD): cytosolic or copper-zinc SOD (CuZn-SOD), manganese SOD (Mn-SOD) localized in mitochondria, and an extracellular form of CuZn-SOD (EC-SOD). Because there are no selective pharmacological inhibitors of individual SOD isoforms, the functional importance of the different SODs has been difficult to define. Recent molecular approaches, primarily the use of genetically-altered mice and viral-mediated gene transfer, have allowed investigators to begin to define the role of specific SOD isoforms in vascular biology. This review will focus mainly on the role of individual SODs in relation to endothelium under normal conditions and in disease states. This area is important because reactive oxygen species and superoxide anion are thought to play major roles in changes in vascular structure and function in pathophysiology.
Details
- Title: Subtitle
- Vascular protection: superoxide dismutase isoforms in the vessel wall
- Creators
- Frank M Faraci - Department of Internal Medicine, Cardiovascular Center, University of Iowa, Carver College of Medicine, Iowa City, IA 52242-1081, USA. frank-faraci@uiowa.eduSean P Didion
- Resource Type
- Journal article
- Publication Details
- Arteriosclerosis, thrombosis, and vascular biology, Vol.24(8), pp.1367-1373
- Publisher
- United States
- DOI
- 10.1161/01.ATV.0000133604.20182.cf
- PMID
- 15166009
- ISSN
- 1079-5642
- eISSN
- 1524-4636
- Grant note
- HL-38901 / NHLBI NIH HHS HL-62984 / NHLBI NIH HHS NS-24621 / NINDS NIH HHS
- Language
- English
- Date published
- 08/2004
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040376502771
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