Journal article
Vascular smooth muscle function is associated with initiation and processing speed in patients with atherosclerotic vascular disease
Journal of the International Neuropsychological Society, Vol.14(4), pp.535-541
07/2008
DOI: 10.1017/S1355617708080697
PMCID: PMC3597121
PMID: 18577282
Abstract
We previously reported a relationship between forearm resistance vessel function and global neuropsychological performance in patients with atherosclerotic vascular disease (AVD). This study was conducted to determine the relationships among vascular smooth muscle function, endothelial function, and initiation and processing speed in this sample. Participants were 80 individuals with AVD. Resistance vessel function was measured before and after infusion of vasoactive agents. Neuropsychological assessment included measures of estimated premorbid cognitive function, current global cognitive function, initiation, and processing speed. Vascular smooth muscle function was significantly associated with the initiation/processing speed composite score [R-Square Change = .152;
F
Change (1,71) = 16.61;
p
< .001], above and beyond the variance accounted for by age, education, premorbid cognitive function, and endothelium-dependent vascular function. This relationship remained significant when controlling for current level of global cognitive functioning and 10 vascular risk factors. Endothelium-dependent vascular function was not significantly associated with test performance. Decreased vascular smooth muscle function in forearm resistance vessels was significantly associated with relatively poor initiation and processing speed in individuals with AVD. With additional research, measures of vascular function might become useful in the early identification of those individuals at greatest risk for vascular-related cognitive dysfunction.
Details
- Title: Subtitle
- Vascular smooth muscle function is associated with initiation and processing speed in patients with atherosclerotic vascular disease
- Creators
- DAVID J MOSER - Department of Internal Medicine, General Clinical Research Center, University of Iowa Carver College of Medicine, Iowa City, IowaIVY N MILLER - Department of Internal Medicine, General Clinical Research Center, University of Iowa Carver College of Medicine, Iowa City, IowaKARIN F HOTH - Department of Internal Medicine, General Clinical Research Center, University of Iowa Carver College of Medicine, Iowa City, IowaMARCELO CORREIA - Department of Internal Medicine, General Clinical Research Center, University of Iowa Carver College of Medicine, Iowa City, IowaSTEPHAN ARNDT - Department of Internal Medicine, General Clinical Research Center, University of Iowa Carver College of Medicine, Iowa City, IowaWILLIAM G HAYNES - Department of Internal Medicine, General Clinical Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of the International Neuropsychological Society, Vol.14(4), pp.535-541
- DOI
- 10.1017/S1355617708080697
- PMID
- 18577282
- PMCID
- PMC3597121
- NLM abbreviation
- J Int Neuropsychol Soc
- ISSN
- 1355-6177
- eISSN
- 1469-7661
- Grant note
- K23 AG020649 || AG / National Institute on Aging : NIA
- Language
- English
- Date published
- 07/2008
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; Biostatistics; Nursing; Injury Prevention Research Center; Medicine Administration; Internal Medicine
- Record Identifier
- 9984003948202771
Metrics
33 Record Views