Journal article
Vasoconstrictor responsiveness in resting and contracting skeletal muscle following an acute bout of exercise: Impact of aging
Journal of applied physiology (1985), Vol.139(4), pp.976-987
10/01/2025
DOI: 10.1152/japplphysiol.00549.2025
PMID: 40924692
Abstract
Long-term exercise training can attenuate sympathetic vasoconstriction in both resting and contracting skeletal muscle; however, the impact of an acute bout of exercise on vasoconstrictor responsiveness and the influence of aging is unknown. Therefore, we tested the hypothesis that an acute bout of exercise will blunt sympathetic-mediated vasoconstriction in resting and contracting skeletal muscle of young and older adults. Twenty-one adults (10 Young: 23±5 yr and 11 Older: 65±8 yr) performed a rest and a rhythmic handgrip exercise trial before and after either 30 minutes of cycling exercise (60-65% HRmax) or a time control period (seated rest). Lower body negative pressure (- 30mmHg) was applied during each trial to induce sympathetic-mediated vasoconstriction. Forearm blood flow (FBF; ml/min) was assessed via Doppler ultrasound and forearm vascular conductance (FVC; ml·min
·100 mmHg
) was calculated as the quotient of FBF and mean arterial pressure (mmHg). The acute bout of cycling exercise did not change vasoconstrictor responsiveness (% change FVC) in resting skeletal muscle in either age group (P>0.05). However, vasoconstrictor responsiveness was attenuated in contracting skeletal muscle following the acute bout cycling exercise in the group (-11.0 ± 5.7 to -8.2 ± 5.1%, P<0.001), as well as separated by age (Young: -6.7 ± 3.2 to -5.0 ± 4.0%, Older: -14.9 ± 4.6 to -11.0 ± 4.2%, P<0.01 for both). Our data indicate that an acute bout of exercise does not change vasoconstrictor responsiveness in resting skeletal muscle but enhances functional sympatholysis in young and older adults.
Details
- Title: Subtitle
- Vasoconstrictor responsiveness in resting and contracting skeletal muscle following an acute bout of exercise: Impact of aging
- Creators
- DongNyeuck Seo - University of IowaJack E Shelley - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, IowaErika Iwamoto - Sapporo Medical UniversityDarren P Casey - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.139(4), pp.976-987
- DOI
- 10.1152/japplphysiol.00549.2025
- PMID
- 40924692
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Publisher
- American Physiological Society
- Language
- English
- Electronic publication date
- 09/09/2025
- Date published
- 10/01/2025
- Academic Unit
- Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984961104802771
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