Journal article
Vasodilator Action of Guanethidine
Circulation research, Vol.11(5), pp.788-796
11/1962
DOI: 10.1161/01.RES.11.5.788
PMID: 14010558
Abstract
The cardiovascular effects of intravenous guanethidine were measured in animals treated with reserpine. The action of intraarterial guanethidine was studied also in perfused forelegs of dogs. The following conclusions were reached:1. There was no significant increase in cardiac output, heart rate, or systemic arterial pressure following intravenous guanethidine in treated animals; only sustained vasodilatation was observed.2. The vasodilatation was caused by a local action of the drug on vascular smooth muscle. The dilatation became more pronounced following depletion of catecholamines with reserpine and repeated administration of guanethidine.3. The dilatation did not appear to be mediated through the release of catecholamines, histamine, or acetylcholine. It may have resulted, at least in part, from stimulation of beta adrenergic receptors or other “dilator receptors” which are blocked by dichloroisoproterenol.
Details
- Title: Subtitle
- Vasodilator Action of Guanethidine
- Creators
- Francois Abboud - Hemodynamic Laboratory, Cardiovascular Research Laboratories, Department of Internal Medicine, State University of Iowa, College of Medicine Iowa City, IowaJohn Eckstein
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.11(5), pp.788-796
- DOI
- 10.1161/01.RES.11.5.788
- PMID
- 14010558
- NLM abbreviation
- Circ Res
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Publisher
- American Heart Association, Inc
- Language
- English
- Date published
- 11/1962
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025680602771
Metrics
11 Record Views