Vasomotor projections from the anteroventral third ventricle (AV3V) region

M M Knuepfer; A K Johnson; M J Brody

doi:10.1152/ajpheart.1984.247.1.h139

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Vasomotor projections from the anteroventral third ventricle (AV3V) region

Journal article

Peer reviewed

Vasomotor projections from the anteroventral third ventricle (AV3V) region

M M Knuepfer, A K Johnson and M J Brody

The American journal of physiology, Vol.247(1 Pt 2), pp.H139-H145

07/1984

DOI: 10.1152/ajpheart.1984.247.1.h139

PMID: 6377926

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Abstract

The anteroventral third ventricle (AV3V) region is necessary for the development of a variety of models of experimental hypertension. Neuroanatomic studies have identified descending projections from this region to the mesencephalic central gray and tegmentum. This study was done to identify functionally the projections involved in cardiovascular regulation from the AV3V region to the mesencephalon. Regional hemodynamic responses to electrical stimulation of the AV3V region were compared with responses to stimulation of the rostral central gray, and these responses were compared before and after ablation of mesencephalic tissue. Stimulation of the AV3V region elicited hindquarter, vasodilation and renal and mesenteric vasoconstriction associated with a depressor response and bradycardia. These responses were partially dependent on adrenal catecholamines since adrenalectomy reduced hindquarter, mesenteric, and depressor responses. Regional hemodynamic responses to central gray stimulation were qualitatively similar and also demonstrated a partial dependence on adrenal catecholamines. After electrolyte ablation of central gray tissue, significant reductions in hindquarter, mesenteric, and depressor responses to AV3V stimulation were observed. These observations suggest that a cardiovascular control system important for the development of several models of hypertension may be dependent on neuronal projections from the rostral medial hypothalamus through the mesencephalic central gray.

Adrenal Glands - physiology

Adrenalectomy

Animals

Blood Pressure

Cerebral Ventricles - anatomy & histology

Cerebral Ventricles - physiology

Electric Stimulation

Epinephrine - physiology

Hemodynamics

Male

Neural Pathways - physiology

Periaqueductal Gray - anatomy & histology

Periaqueductal Gray - physiology

Rats

Rats, Inbred Strains

Regional Blood Flow

Stereotaxic Techniques

Vascular Resistance

Vasomotor System - anatomy & histology

Vasomotor System - physiology

Details

Title: Subtitle: Vasomotor projections from the anteroventral third ventricle (AV3V) region
Creators: M M Knuepfer
A K Johnson
M J Brody
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.247(1 Pt 2), pp.H139-H145
DOI: 10.1152/ajpheart.1984.247.1.h139
PMID: 6377926
ISSN: 0002-9513
eISSN: 2163-5773
Grant note: 1-K02-MH00064 / NIMH NIH HHS HLP-14388 / NHLBI NIH HHS GM-07069 / NIGMS NIH HHS
Language: English
Date published: 07/1984
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
Record Identifier: 9984213422202771

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