Journal article
Vasopressin for refractory persistent pulmonary hypertension of the newborn in preterm neonates - a case series
The journal of maternal-fetal & neonatal medicine, Vol.35(8), pp.1475-1483
04/18/2022
DOI: 10.1080/14767058.2020.1757642
PMID: 32349572
Abstract
To describe the clinical outcomes following treatment with vasopressin for a sub-cohort of critically ill preterm neonates who have refractory persistent pulmonary hypertension of the newborn (PPHN).
Case series
Tertiary neonatal intensive care unit, Toronto, Canada.
Neonates born <37 weeks gestational age (GA) who received vasopressin for refractory PPHN (lack of response to inhaled nitric oxide) over a 4-year period.
Changes in physiological indices of cardio-pulmonary stability during vasopressin therapy were analyzed using one-way repeated measures ANOVA, compared to pretreatment values. Data regarding survival to discharge and neurodevelopmental outcomes at 18-24 months were described.
Thirteen neonates with a mean GA of 31.4 ± 3.3 weeks were included. Vasopressin was initiated at 28.5 ± 4.5 h of age. Overall, oxygenation and hemodynamic variables improved significantly following vasopressin therapy (p < .05 at 24 h vs. pretreatment). Oxygenation failure resolved in 8 cases, of which 7 patients survived (6 without disability). Among the 5 cases where oxygenation failure persisted despite vasopressin, 4 died while one survived with disability.
Vasopressin offers promise as a therapy for preterm neonates with refractory PPHN and hemodynamic instability, but prospective investigation is needed.
Details
- Title: Subtitle
- Vasopressin for refractory persistent pulmonary hypertension of the newborn in preterm neonates - a case series
- Creators
- Adel A. Mohamed - Mount Sinai HospitalDeepak Louis - Mount Sinai HospitalAimann Surak - Mount Sinai HospitalDany E. Weisz - Sunnybrook HospitalPatrick J. McNamara - Hospital for Sick ChildrenAmish Jain - Mount Sinai Hospital
- Resource Type
- Journal article
- Publication Details
- The journal of maternal-fetal & neonatal medicine, Vol.35(8), pp.1475-1483
- Publisher
- Taylor & Francis
- DOI
- 10.1080/14767058.2020.1757642
- PMID
- 32349572
- ISSN
- 1476-7058
- eISSN
- 1476-4954
- Language
- English
- Date published
- 04/18/2022
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984353845902771
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